161877-70-9 Usage
Description
DABCYL-TYR-VAL-ALA-ASP-ALA-PRO-VAL-EDANS is a synthetic peptide sequence composed of the amino acids tyrosine, valine, alanine, aspartic acid, proline, and valine. This sequence is distinctively labeled with the fluorophores DABCYL at the N-terminus and EDANS at the C-terminus. The DABCYL molecule serves as a fluorescence quencher, effectively suppressing the fluorescence of nearby fluorophores, whereas EDANS is a fluorophore that emits a strong fluorescence signal upon excitation. The strategic pairing of these fluorophores and quencher in the peptide sequence allows it to function as a fluorescence resonance energy transfer (FRET) pair, which is widely utilized in biological research to investigate molecular interactions and proximities.
Uses
Used in Biochemical Research:
DABCYL-TYR-VAL-ALA-ASP-ALA-PRO-VAL-EDANS is used as a fluorescence resonance energy transfer (FRET) pair for studying molecular interactions and the proximity of molecules within biological systems. The fluorescence of EDANS is quenched by the adjacent DABCYL, and changes in fluorescence can indicate conformational changes, binding events, or other interactions occurring between molecules of interest.
Used in Drug Development:
In the pharmaceutical industry, this peptide sequence can be employed as a tool for high-throughput screening of potential drug candidates. By monitoring changes in FRET efficiency, researchers can quickly assess the binding affinity and specificity of drug molecules to their target proteins.
Used in Diagnostics:
DABCYL-TYR-VAL-ALA-ASP-ALA-PRO-VAL-EDANS can be utilized in the development of diagnostic assays to detect specific biomolecular interactions. The FRET-based detection system allows for sensitive and specific measurement of molecular interactions, which can be applied to detect the presence of certain proteins, enzymes, or other biomolecules in biological samples.
Used in Biosensors:
This peptide sequence can be integrated into the design of biosensors, where changes in FRET efficiency can be correlated with the binding or activity of target molecules. Such biosensors can be used for real-time monitoring of enzymatic activity, protein-protein interactions, or other biological processes in research and clinical settings.
Check Digit Verification of cas no
The CAS Registry Mumber 161877-70-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,6,1,8,7 and 7 respectively; the second part has 2 digits, 7 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 161877-70:
(8*1)+(7*6)+(6*1)+(5*8)+(4*7)+(3*7)+(2*7)+(1*0)=159
159 % 10 = 9
So 161877-70-9 is a valid CAS Registry Number.
InChI:InChI=1/C61H76N12O14S/c1-34(2)52(63-30-29-62-46-14-9-13-45-44(46)12-10-16-50(45)88(85,86)87)59(82)69-58(81)49-15-11-31-73(49)61(84)37(6)65-56(79)48(33-51(75)76)66-54(77)36(5)64-60(83)53(35(3)4)68-57(80)47(32-38-17-27-43(74)28-18-38)67-55(78)39-19-21-40(22-20-39)70-71-41-23-25-42(26-24-41)72(7)8/h9-10,12-14,16-28,34-37,47-49,52-53,62-63,74H,11,15,29-33H2,1-8H3,(H,64,83)(H,65,79)(H,66,77)(H,67,78)(H,68,80)(H,75,76)(H,69,81,82)(H,85,86,87)/b71-70+/t36-,37-,47-,48-,49-,52-,53-/m0/s1
