16191-32-5Relevant articles and documents
Gold(I)-catalyzed furan-yne cyclizations involving 1,2-rearrangement: Efficient synthesis of functionalized 1-naphthols and its application to the synthesis of wailupemycin g
Chen, Yifeng,Wang, Lu,Sun, Ning,Xie, Xin,Zhou, Xiaobo,Chen, Haoyi,Li, Yuxue,Liu, Yuanhong
, p. 12015 - 12019 (2014)
Gold-catalyzed cascade cyclization/1,2-rearrangement of 1-(2-furanyl)phenyl propargyl alcohols has been developed, which provides a rapid and efficient access to multisubstituted 1-naphthols bearing an enal or enone moiety with high stereoselectivity. The (Z)- or (E)-stereochemistry can be easily controlled by choosing protected- or non-protected substrates. The utility of the methodology has been illustrated in the first total synthesis of wailupemycin G.
Gold-catalyzed spirocyclization of furan-ynones and unexpected skeleton rearrangement of the resulting spirohydrofurans
Chen, Yulong,Xu, Wei,Xie, Xin,Pei, Miaomiao,Lu, Mingduo,Wang, Yaotong,Liu, Yuanhong
supporting information, p. 1090 - 1095 (2021/02/01)
A gold-catalyzed cyclization of aniline-tethered furan-ynones has been developed. The reaction proceeds via trapping of the resulting stabilized cationic intermediate with an amide group leading to polycycles featured with a spiro-cyclohexadienonehydrofur
Based on 4 - phenyl -6 - (2, 2, 2 - trifluoro -1 - phenyl ethoxy) pyrimidine compound and its application method
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Paragraph 0342, (2017/08/25)
The present invention relates to compounds based on 4-phenyl-6-(2,2,2-trifluoro-1-phenyl ethoxy) pyrimidine and an application method thereof, particularly discloses compounds of formula I and compositions comprising the compounds, and the application method thereof in treatment, prevention and / or management of diseases or disorders.