1620-21-9 Usage
Description
Chlorcyclizine Hydrochloride, also known as 1-(p-chloro-α-phenylbenzyl)-4-methylpiperazine monohydrochloride, is a light-sensitive, white crystalline powder that is soluble in water, alcohol, and chloroform. It is characterized by its ability to provide symptomatic relief for various conditions, such as urticaria and hay fever, due to its H1-antihistamine properties.
Uses
Used in Pharmaceutical Industry:
Chlorcyclizine Hydrochloride is used as an H1-antihistamine for the symptomatic relief of conditions like urticaria, hay fever, and other related conditions. Its effectiveness in providing relief is attributed to its ability to block the action of histamine, a compound responsible for causing allergic symptoms.
Originator
Perazil,Burroughs-Wellcome,US,1949
Manufacturing Process
0.08 mol (19 9) of 4-chlorobenzhydryl chloride and 0.16 mol (16 g) of
methylpiperazine were mixed in about 20 cc of dry benzene. The flask
containing the reaction mixture was covered by a watch glass and set in a
steam bath, and heating was continued for 6 hours. The contents of the flask
were partitioned between ether and water and the ethereal layer was washed
with water until the washings were neutral. The ethereal layer was extracted
successively with 30 and 10 cc portions of 3 N hydrochloric acid. On
evaporation of the ether layer there remained a residue of 2.5 9. The aqueous
extracts were united and basified with concentrated alkali. The oily base was
taken into ether and dried over potassium carbonate. On evaporation of the
ether, N-methyl-N'-(4-chlorobenzhydryl) piperazine was recovered in the form
of a viscous oil in 75% yield. The N-methyl-N'-(4-chlorobenzhydryl) piperazine
was dissolved in absolute alcohol and ethanolic hydrogen chloride added in
excess. The dihydrochloride crystallized on addition of absolute ether and was
recrystallized from the same solvent mixture in the form of longish prisms
melting at about 216°C.
Therapeutic Function
Antihistaminic
Check Digit Verification of cas no
The CAS Registry Mumber 1620-21-9 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,6,2 and 0 respectively; the second part has 2 digits, 2 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 1620-21:
(6*1)+(5*6)+(4*2)+(3*0)+(2*2)+(1*1)=49
49 % 10 = 9
So 1620-21-9 is a valid CAS Registry Number.
InChI:InChI=1/C18H21ClN2.ClH/c1-20-11-13-21(14-12-20)18(15-5-3-2-4-6-15)16-7-9-17(19)10-8-16;/h2-10,18H,11-14H2,1H3;1H