1620220-63-4Relevant articles and documents
Fast and Efficient Postsynthetic DNA Labeling in Cells by Means of Strain-Promoted Sydnone-Alkyne Cycloadditions
Krell, Katja,Pfeuffer, Bastian,R?nicke, Franziska,Chinoy, Zoeisha S.,Favre, Camille,Friscourt, Frédéric,Wagenknecht, Hans-Achim
, p. 16093 - 16097 (2021/11/03)
Sydnones are highly stable mesoionic 1,3-dipoles that react with cyclooctynes through strain-promoted sydnone-alkyne cycloaddition (SPSAC). Although sydnones have been shown to be valuable bioorthogonal chemical reporters for the labeling of proteins and
SYDNONE DERIVATIVES FOR CONJUGATION OF COMPOUNDS OF INTEREST
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Paragraph 0214-0215, (2017/04/11)
The present invention relates to a process for the preparation of a first compound of interest C1 functionalized with a sydnone compound and to the corresponding functionalized C1 compound of interest. The present invention also relates to a process for the preparation of a conjugate of two compounds of interest C1 and C2 implying a sydnone compound and to the obtained conjugate. The present invention also relates to a process for preparing a compound of interest C2 comprising a strained alkyne moiety functionalized with a sydnone and to the corresponding functionalized compound of interest C2. It also relates to novel sydnone compounds substituted in position 4, which may be used in the above processes.