162054-19-5 Usage
Description
1-[(4-METHYLSULFONYL)PHENYL]-3-TRIFLUOROMETHYL-5-(4-FLUOROPHENYL)PYRAZOLE, also known as SC-58125, is a member of the class of pyrazoles. It is a 1H-pyrazole derivative that is substituted by a 4-fluorophenyl group at position 5, a 4-(methylsulfonyl)phenyl group at position 1, and a trifluoromethyl group at position 3. 1-[(4-METHYLSULFONYL)PHENYL]-3-TRIFLUOROMETHYL-5-(4-FLUOROPHENYL)PYRAZOLE is a selective cyclooxygenase 2 (COX-2) inhibitor and exhibits both anti-inflammatory and anticancer properties. It is a white to off-white solid.
Uses
Used in Pharmaceutical Industry:
1-[(4-METHYLSULFONYL)PHENYL]-3-TRIFLUOROMETHYL-5-(4-FLUOROPHENYL)PYRAZOLE is used as a selective COX-2 inhibitor for its anti-inflammatory properties. It is effective in blocking edema and hyperalgesia without causing gastric mucosal damage, making it a potential candidate for the treatment of various inflammatory conditions.
Used in Oncology:
In the field of oncology, 1-[(4-METHYLSULFONYL)PHENYL]-3-TRIFLUOROMETHYL-5-(4-FLUOROPHENYL)PYRAZOLE is used for its anticancer property. It has been shown to exhibit antitumor activity, making it a promising compound for the development of novel cancer treatments.
Used in Drug Development:
1-[(4-METHYLSULFONYL)PHENYL]-3-TRIFLUOROMETHYL-5-(4-FLUOROPHENYL)PYRAZOLE is also used in drug development as a starting point for the synthesis of new compounds with potential therapeutic applications. Its unique chemical structure and biological activities make it an interesting candidate for further research and development in the pharmaceutical industry.
Biological Activity
Selective cyclooxygenase 2 (COX-2) inhibitor (IC 50 values are 0.04 and >100 μ M for COX-2 and COX-1 respectively). Anti-inflammatory; blocks edema and hyperalgesia in vivo following an inflammatory insult, without causing gastric mucosal damage. Also displays antitumor activity.
Check Digit Verification of cas no
The CAS Registry Mumber 162054-19-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,6,2,0,5 and 4 respectively; the second part has 2 digits, 1 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 162054-19:
(8*1)+(7*6)+(6*2)+(5*0)+(4*5)+(3*4)+(2*1)+(1*9)=105
105 % 10 = 5
So 162054-19-5 is a valid CAS Registry Number.
InChI:InChI=1/C17H12F4N2O2S/c1-26(24,25)14-8-6-13(7-9-14)23-15(10-16(22-23)17(19,20)21)11-2-4-12(18)5-3-11/h2-10H,1H3
162054-19-5Relevant articles and documents
Pyrazole derivatives as anti-francisella agents
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Page/Page column 10-11, (2010/11/17)
A series of celecoxib derivatives defined by Formula I: were prepared and evaluated for their ability to inhibit the gram-negative bacteria Francisella tularensis. Pharmaceutical compositions including celecoxib derivatives and their use in methods for treating or preventing infection by Francisella tularensis in a subject are described.
METHOD OF USING CYCLOOXYGENASE-2 INHIBITORS IN THE TREATMENT AND PREVENTION OF NEOPLASIA
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, (2008/06/13)
This invention relates to the use of cyclooxygenase-2 inhibitors or derivatives thereof in preventing and treating neoplasia. In particular, the invention describes the method of preventing and treating epithelial cell neoplasia in a subject, said method comprising treating the subject with a therapeutically-effective amount of a compound of Formula (I) wherein A, R and R are as described in the specification.
Method for the treatment and prevention of cachexia
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, (2008/06/13)
Cachexia, including anorexia and other forms of weight loss, is a frequent complication of acute and chronic infections, and result from induction of cytokines, prostaglandins, and other inflammatory mediators that are critical for pathogen elimination. The present invention includes methods for the treatment or prevention of cachexic conditions while maintaining the production of factors essential for infection control through the administration of an effective amount of a cyclooxygenase-2 selective inhibiting compound.
