1620842-13-8

Basic information

• Product Name: 4⁽⁵⁾-(o-fluorophenylmethyl)-DL-histidine
• Synonyms: 4⁽⁵⁾-(o-fluorophenylmethyl)-DL-histidine
• CAS NO: 1620842-13-8
• Molecular Weight: 263.271
• Mol File: 1620842-13-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4⁽⁵⁾-(o-fluorophenylmethyl)-DL-histidine(CAS DataBase Reference)
• NIST Chemistry Reference: 4⁽⁵⁾-(o-fluorophenylmethyl)-DL-histidine(1620842-13-8)
• EPA Substance Registry System: 4⁽⁵⁾-(o-fluorophenylmethyl)-DL-histidine(1620842-13-8)

Safety Data

• Hazardous Substances Data: 1620842-13-8(Hazardous Substances Data)

Upstream product

• 446-52-6 2-Fluorobenzaldehyde 
• 6459-59-2 2-amino-3-(3H-imidazol-4-yl)propanoic acid hydrochloride 
• 1048031-77-1 C₁₃H₁₂FN₃O₂ 

Relevant articles and documents

An efficient synthesis of 4(5)-benzyl- L -histidines employing catalytic transfer hydrogenolysis at elevated temperatures

An efficient two-step synthesis of 4(5)-benzyl-l-histidine from l-histidine was developed. A Pictet-Spengler reaction between l-histidine and benzaldehyde in the presence of excess strong base yielded 4-l-phenylspinacine within one hour. Catalytic transfer hydrogenolysis in methanol at reflux using ammonium formate rapidly converted 4-l-phenylspinacine to 4(5)-benzyl-l-histidine within five minutes. No racemization of the final product 4(5)-benzyl-l-histidine was observed using the Marfey reagent. To show the utility of this method, a series of fluorinated benzylhistidines were prepared.