162103-13-1

Basic information

• Product Name: 4-(4-methoxyphenyl)-<2.2>paracyclophane
• Synonyms: 4-(4-methoxyphenyl)-<2.2>paracyclophane
• CAS NO: 162103-13-1
• Molecular Weight: 314.427
• Mol File: 162103-13-1.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 4-(4-methoxyphenyl)-<2.2>paracyclophane(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(4-methoxyphenyl)-<2.2>paracyclophane(162103-13-1)
• EPA Substance Registry System: 4-(4-methoxyphenyl)-<2.2>paracyclophane(162103-13-1)

Safety Data

• Hazardous Substances Data: 162103-13-1(Hazardous Substances Data)

Upstream product

• 1908-61-8 4-bromo[2.2]paracyclophane 
• 104-92-7 1-bromo-4-methoxy-benzene 

Downstream Products

• 206560-01-2 (C₂₃H₂₂O)Cr(CO)3 
• 206560-02-3 (C₂₃H₂₂O)Cr(CO)3 
• 206560-03-4 (C₂₃H₂₂O)Cr₂(CO)6 

Relevant articles and documents

Preparation and Synthetic Applications of [2.2]Paracyclophane Trifluoroborates: An Efficient and Convenient Route to Nucleophilic [2.2]Paracyclophane Cross-Coupling Building Blocks

We report the synthesis of [2.2]paracyclophane (PCP) trifluoroborate building blocks that can be used for the incorporation of the PCP moiety into a wide range of (hetero)aryl chlorides, bromides and triflates by a Pd(II)/RuPhos mediated Suzuki–Miyaura cross-coupling reaction. The PCP trifluoroborate species are bench stable with extended shelf life and easily accessible on a multigram scale by a two-step synthesis from commercially available PCP. They can be handled conveniently without special precautions, thus overcoming many of the limitations of other PCP cross-coupling reagents. Additionally, a high yielding regioselective monolithiation/borylation protocol for the synthesis of pseudo-para and pseudo-ortho PCP halotrifluoroborates and their subsequent Suzuki–Miyaura cross-coupling are described.