1621387-20-9

Basic information

• Product Name: 1-(1-bromovinyl)-2-fluorobenzene
• Synonyms: 1-(1-bromovinyl)-2-fluorobenzene
• CAS NO: 1621387-20-9
• Molecular Weight: 201.038
• Mol File: 1621387-20-9.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: 1-(1-bromovinyl)-2-fluorobenzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(1-bromovinyl)-2-fluorobenzene(1621387-20-9)
• EPA Substance Registry System: 1-(1-bromovinyl)-2-fluorobenzene(1621387-20-9)

Safety Data

• Hazardous Substances Data: 1621387-20-9(Hazardous Substances Data)

Upstream product

• 394-46-7 2-fluorostyrene 
• 1621387-16-3 1-(1,2-dibromoethyl)-2-fluorobenzene 
• 766-49-4 (2-fluorophenyl)acetylene 
• 74-95-3 1,1-dibromomethane 

Downstream Products

• 1621387-27-6 C₈H₈BFO₂ 
• 1621387-12-9 2-((1-(2-fluorophenyl)vinyl)oxy)isoindoline-1,3-dione 
• 898753-32-7 ethyl 4-(2-fluorophenyl)-4-oxobutanoate 

Relevant articles and documents

Synthesis of Unsymmetrical 1,4-Dicarbonyl Compounds by Photocatalytic Oxidative Radical Additions

Herein we report a photocatalytic oxidative radical addition reaction for the synthesis of unsymmetrical 1,4-dicarbonyl compounds. This reaction utilizes a desulfurization process to generate electrophilic radicals, which add to α-halogenated alkenes and undergo further oxidation to deliver 1,4-dicarbonyl compounds. This mild and highly efficient method provides a valuable alternative to known strategies.

A Cascade Suzuki-Miyaura/Diels-Alder Protocol: Exploring the Bifunctional Utility of Vinyl Bpin

Cascade reactions are an important strategy in reaction design, allowing streamlining of chemical synthesis. Here we report a cascade Suzuki-Miyaura/Diels-Alder reaction, employing vinyl Bpin as a bifunctional reagent in two distinct roles: as an organoboron nucleo phile for cross-coupling and as a Diels-Alder dienophile. Merging these two reactions enables a rapid and operationally simple synthesis of functionalized carbocycles in good yield. The effect of the organoboron subtype on Diels-Alder regioselectivity was investigated and postsynthetic modifications were carried out on a model substrate. The potential for a complementary Heck/Diels-Alder process was also assessed.

Rh(III)-Catalyzed C-H Activation-Initiated Directed Cyclopropanation of Allylic Alcohols

We have developed a Rh(III)-catalyzed diastereoselective [2+1] annulation onto allylic alcohols initiated by alkenyl C-H activation of N-enoxyphthalimides to furnish substituted cyclopropyl-ketones. Notably, the traceless oxyphthalimide handle serves three functions: Directing C-H activation, oxidation of Rh(III), and, collectively with the allylic alcohol, in directing cyclopropanation to control diastereoselectivity. Allylic alcohols are shown to be highly reactive olefin coupling partners leading to a directed diastereoselective cyclopropanation reaction, providing products not accessible by other routes.