16214-14-5

Basic information

• Product Name: Benzene, 4-(chloromethyl)-1-methoxy-2-(1-methylethyl)-
• Synonyms: 3-Isopropyl-4-methoxybenzylchlorid;Benzene,4-(chloromethyl)-1-methoxy-2-(1-methylethyl);4-Methoxy-3-isopropylbenzyl chloride;3-isopropyl-4-methoxybenzyl chloride
• CAS NO: 16214-14-5
• Molecular Formula: C11H15ClO
• Molecular Weight: 198.692
• Mol File: 16214-14-5.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 279.0±28.0 °C(Predicted)
• Density: 1.039±0.06 g/cm3(Predicted)
• CAS DataBase Reference: Benzene, 4-(chloromethyl)-1-methoxy-2-(1-methylethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzene, 4-(chloromethyl)-1-methoxy-2-(1-methylethyl)-(16214-14-5)
• EPA Substance Registry System: Benzene, 4-(chloromethyl)-1-methoxy-2-(1-methylethyl)-(16214-14-5)

Safety Data

• Hazardous Substances Data: 16214-14-5(Hazardous Substances Data)

Upstream product

• 31816-29-2 4-Methoxy-3-isopropylbenzyl alcohol 
• 50-00-0 formaldehyd 
• 2944-47-0 o-isopropylanisole 
• 33537-78-9 4-Methoxy-3-isopropylbenzoic acid 
• 105401-95-4 3-isopropyl-4-methoxy-benzoic acid methyl ester 
• 88-69-7 2-(1-methylethyl)phenol 
• 24591-33-1 4-bromo-2-isopropylanisole 
• 31825-29-3 3‐isopropyl‐4‐methoxybenzaldehyde 

Downstream Products

• 77012-37-4 (E)-4-(4,8-dimethylnona-3,7-dien-1-yl)-2-isopropyl-1-methoxybenzene 
• 77017-48-2 1,2-di-(4-Methoxy-3-isopropylphenyl)ethane 
• 514-62-5 ferruginol 
• 511-05-7 sugiol 
• 64158-71-0 (+/-)-12-Benzoyloxyabieta-8,11,13-trien-6β,11-diol 
• 514-62-5 (+/-)-ferruginol 
• 64158-62-9 2-(3-Isopropyl-4-methoxy-phenyl)-1-(2,6,6-trimethyl-cyclohex-1-enyl)-ethanone 
• 70022-65-0 3-(3-isopropyl-4-methoxystyryl)-2,4,4,-trimethyl-1-cyclohexene 
• 64158-72-1 2-Isopropyl-1-methoxy-4-[2-(2,6,6-trimethyl-cyclohex-1-enyl)-ethyl]-benzene 
• 77012-39-6 C₂₁H₃₂O₃ 
• 18326-13-1 (+/-)-Hinokiol methyl ether 
• 77012-38-5 (6E)-2,3-Epoxy-9-(4-methoxy-3-isopropylphenyl)-2,6-dimethylnon-6-ene 
• 627079-51-0 2-(3-isopropyl-4-methoxyphenyl)-1-(2,6,6-trimethylcyclohex-2-enyl)ethanone 
• 627079-50-9 2-(4-methoxy-3-isopropylphenyl)-1-(2,6,6-trimethylcyclohex-2-enyl)ethanol 

Relevant articles and documents

Enantioselective, Lewis Base-Catalyzed Sulfenocyclization of Polyenes

A sulfenium-ion-initiated, catalytic, enantioselective polyene cyclization is described. Homogeranylarenes and ortho-geranylphenols undergo polycyclization in good yield, diastereoselectivity, and enantioselectivity. The stereodetermining step is the generation of an enantiomerically enriched thiiranium ion from a terminal alkene and a sulfenylating agent in the presence of a chiral Lewis basic catalyst. The use of hexafluoroisopropyl alcohol as the solvent is crucial to obtain good yields. The thioether moiety resulting from the reaction can be subsequently transformed into diverse oxygen and carbon functionality postcyclization. The utility of this method is demonstrated by the enantioselective syntheses of (+)-ferruginol and (+)-hinokiol.

Cyclisation Reactions: Part VI - Further Study in Biogenetic-type Cyclisation of Epoxy-Olefins

(6E)-9-p-Methoxyphenyl-2,6-dimethylnona-2,6-diene (I) on mono-epoxidation affords mainly 2,3-epoxyolefin (IV) admixed with some 6,7-isomer.IV on cyclisation with boron trifluoride etherate furnishes three ketones: 7-oxo-9-p-methoxyphenyl-2,6-dimethylnon-2-ene (XIII) presumably formed from 6,7-epoxyolefin (XII), cis-3-(2-p-methoxyphenylethyl)-2,2,4-trimethylcyclohexanone (XIV) arising out of 1,4-hydride transfer in an intermediate cyclohexyl cation (XVII), and cis-3-(2-p-methoxyphenylethyl)-2,3,4-trimethylcyclohexanone (XV) resulting from three consecutive 1,2-H, Me shifts in the same intermediate.In addition, 12-methoxypodocarpa-8,11,13-trien-3β-ol (IX) is obtained in 10 percent yield.The mono-epoxide (V) from the corresponding 3-isopropyl-4-methoxyphenyldiene (II) on similar cyclisation affords, among others, hinokiol methyl ether (X) and another crystalline compound characterised by PMR and MS as 12-methoxy-13-isopropyl-A-homo-4a-oxapodocarpa-8,11,13-trien-3β-ol (XXII).The latter is formed by a concerted cyclisation of the di-epoxide (XXI) present in the starting material.Contrary to a previous report from this laboratory, it is now found that trans-podocarpa-8,11,13-trienes (XXV) are more stable than the cis-isomers and are almost the sole products of cyclisation of 2-(2-arylethyl)-1,3,3-trimethylcyclohexyl cations (XXIV) and their analogues under thermodynamically controlled condition.

Thyromimetics. VII. Isopropyl analogs of thyroid hormones.

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