162181-63-7

Basic information

• Product Name: (4R,5R)-4-[(3,4-Dimethoxy-phenyl)-bis-phenylsulfanyl-methyl]-5-[(2S,4R)-2,4-diphenyl-3-(toluene-4-sulfonyl)-oxazolidin-2-yl]-dihydro-furan-2-one
• CAS NO: 162181-63-7
• Molecular Weight: 830.059
• Mol File: 162181-63-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (4R,5R)-4-[(3,4-Dimethoxy-phenyl)-bis-phenylsulfanyl-methyl]-5-[(2S,4R)-2,4-diphenyl-3-(toluene-4-sulfonyl)-oxazolidin-2-yl]-dihydro-furan-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: (4R,5R)-4-[(3,4-Dimethoxy-phenyl)-bis-phenylsulfanyl-methyl]-5-[(2S,4R)-2,4-diphenyl-3-(toluene-4-sulfonyl)-oxazolidin-2-yl]-dihydro-furan-2-one(162181-63-7)
• EPA Substance Registry System: (4R,5R)-4-[(3,4-Dimethoxy-phenyl)-bis-phenylsulfanyl-methyl]-5-[(2S,4R)-2,4-diphenyl-3-(toluene-4-sulfonyl)-oxazolidin-2-yl]-dihydro-furan-2-one(162181-63-7)

Safety Data

• Hazardous Substances Data: 162181-63-7(Hazardous Substances Data)

Upstream product

• 707-07-3 orthobenzoic acid trimethyl ester 
• 118917-59-2 (R)-N-(2-hydroxy-1-phenylethyl)-4-methyl-S-methylenebenzenesulfinamide 
• 60354-22-5 4-[Bis(phenylsulfanyl)methyl]-1,2-dimethoxybenzene 
• 162181-53-5 (-)-(2S,4R,5'R)-2-(2'-oxo-2',5'-dihydro-5'-furyl)-2,4-diphenyl-3-(4-methylbenzenesulfonyl)-1,3-oxazolidine 

Relevant articles and documents

Asymmetric synthesis of butenolide and butyrolactone derivatives

2-Trimethylsiloxyfuran and 4-methoxy-2-trimethylsiloxyfuran, which are readily prepared from butenolide and methyl tetronate respectively, have been reacted with a series of homochiral ortho-esters and oxazolidine derivatives in the presence of Lewis acids to afford homochiral 2(5H)-furanone derivatives. The structures of three products have been determined using nmr spectroscopy and, where possible, by X-ray analysis. Preliminary experiments have been carried out involving conjugate addition to these unsaturated lactones, demonstrating their potential as substrates for natural product synthesis.