1622136-46-2 Usage
Description
(S)-praziquanamine-hemi-dibenzoyl-L-tataric acid salt is a chemical compound derived from (S)-praziquantel, an anthelmintic drug used to treat parasitic infections in humans and animals. This salt form is created by combining (S)-praziquantel with hemi-dibenzoyl-L-tartaric acid, which enhances the solubility and bioavailability of the drug. The improved pharmaceutical properties of this salt make it more suitable for oral administration formulations, and it is currently under investigation for its potential to treat various parasitic infections, such as schistosomiasis and other helminth infections.
Uses
Used in Pharmaceutical Industry:
(S)-praziquanamine-hemi-dibenzoyl-L-tataric acid salt is used as an anthelmintic agent for the treatment of parasitic infections. Its improved solubility and bioavailability make it a more effective and convenient option for oral administration, potentially leading to better patient compliance and treatment outcomes.
Used in Research and Development:
(S)-praziquanamine-hemi-dibenzoyl-L-tataric acid salt is also used in the research and development of new treatments for parasitic infections. Its enhanced properties may lead to the discovery of more effective drugs and therapies for a range of helminth infections, contributing to the advancement of medical science in this field.
Check Digit Verification of cas no
The CAS Registry Mumber 1622136-46-2 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,6,2,2,1,3 and 6 respectively; the second part has 2 digits, 4 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 1622136-46:
(9*1)+(8*6)+(7*2)+(6*2)+(5*1)+(4*3)+(3*6)+(2*4)+(1*6)=132
132 % 10 = 2
So 1622136-46-2 is a valid CAS Registry Number.
1622136-46-2Relevant articles and documents
Optically active [...][...] and the corresponding method for the preparation of the
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Paragraph 0037; 0047, (2017/01/26)
The invention provides a preparation method of pyrazino amine salt with optical activity. The preparation method is characterized in that pyrazino amine salt is prepared through the reaction of racemic pyrazino amine and dibenzoyltartaric acid with optical activity in the presence of a solvent, wherein the solvent comprises more than 50% of 2-butanone in volume fraction; and dibenzoyltartaric acid with optical activity is diphenyl diketone-L-tartaric acid with optical impurity not less than 95%, or diphenyl diketone-D-tartaric acid with optical impurity not less than 95%. The invention also provides a preparation method of corresponding pyrazino amine with optical activity. The method performed for separating racemic pyrazino amine is very suitable for industrial application.
Development and validation of process for resolution of praziquantel amine for preparation of chiral praziquantel
Hu, Changyan,Wang, Dongling,Chen, Kunquan,Liu,Chen, Qichao,Sun, Dequn
, p. 8158 - 8162 (2015/02/02)
Investigation of the viability of scale up preparation for chiral praziquantel was included in WHO/TDR business plan. Resolution is the major strategy for preparation of single enantiomer. In this study, a stable and effective resolution approach toward the important intermediate praziquantel amine for preparation of chiral praziquantel was developed and the process was optimized to afford high ee value and good yield. The suitable HPLC method was validated for the determination of ee value of chiral praziquantel amine.
