162255-90-5Relevant articles and documents
Studies on reactions of 3-benzoyl-4-hydroxypyrido[3,2-e]-1,2-thiazines with primary amines and N-methylhydrazine
Malinka,Karczmarzyk,Kaczmarz,Swiatek,Urbanczyk-Lipkowska
, p. 815 - 829 (2007/10/03)
Reaction of the appropriate 3-benzoyl-4-hydroxypyrido[3,2-e]-1,2-thiazine- 1,1-dioxides 2 bearing a methyl or a 3-(4-arylpiperazin-1-yl)propyl group at the nitrogen atom of the thiazine ring with primary amines resulted in enamines of type (E)-3. The related products 8 were obtained by alkylation of 3-phenylpyrazolo[4,3-c]pyrido[3,2-e]-1,2-thiazine-5,5-dioxide 7 with the corresponding 1-aryl-4-(3-chloropropyl)piperazines 9. The structures of the new heterocycles 3 and 8, synthesized for pharmaceutical purposes, and of the model compounds 4-6, prepared for comparison of spectral properties, were proven through elemental, IR, 1H NMR and, in some cases (3d, 8a), X-ray data.