16234-95-0

Basic information

• Product Name: ethyl N-<3-(5H-dibenzocyclohepten-5-ylidene)propyl>-N-methylcarbamate
• CAS NO: 16234-95-0
• Molecular Weight: 333.43
• Mol File: 16234-95-0.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: ethyl N-<3-(5H-dibenzocyclohepten-5-ylidene)propyl>-N-methylcarbamate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl N-<3-(5H-dibenzocyclohepten-5-ylidene)propyl>-N-methylcarbamate(16234-95-0)
• EPA Substance Registry System: ethyl N-<3-(5H-dibenzocyclohepten-5-ylidene)propyl>-N-methylcarbamate(16234-95-0)

Safety Data

• Hazardous Substances Data: 16234-95-0(Hazardous Substances Data)

Upstream product

• 303-50-4 5-[3-(methylamino)propylidene]-5H-dibenzo[a,d]cycloheptene 
• 541-41-3 chloroformic acid ethyl ester 
• 1614-47-7 5-(3-aminopropylidene)-5H-dibenzo[a,d]cycloheptene 
• 1614-63-7 5-ETHYLIDENE-5H-DIBENZO[a,d]CYCLOHEPTENE 
• 1614-61-5 5-(2-cyanoethylidene)-5H-dibenzo[a,d]cycloheptene 
• 1614-62-6 5-(2'-bromoethylidene)-5H-dibenzo[a,d]cycloheptene 
• 1971-54-6 5-ethyl-5-hydroxy-5H-dibenzo[a,d]cycloheptene 
• 2222-33-5 dibenzosuberenon 
• 303-53-7 Cyclobenzaprine 

Downstream Products

• 303-50-4 5-[3-(methylamino)propylidene]-5H-dibenzo[a,d]cycloheptene 

Relevant articles and documents

Study on zwitter-ionization of drugs. II. Synthesis and pharmacological activity of some N-[3-(5H-dibenzo[a,d]cyclohepten-5-ylidene)propyl]-N- methylamino- and N-[3-(6H-dibenz[b,e]oxepin-11-ylidene)propyl]-N-methylamino- alkanoic acid derivatives and related compounds

A series of N-[3-(5H-dibenzo[a,d]cyclohepten-5-ylidene)propyl]-N- methylamino- (6a) and N-[3-(6H-dibenz-[b,e]oxepin-11-ylidene)propyl]-N- methylamino-alkanoic acid derivatives (6b) and related compounds (6c-f) were synthesized and examined for pharmacological activities in vitro, i.e., inhibitory effect on monoamine [noradrenaline (NA) and 5-hydroxytryptamine (5-HT)] uptake, inhibitory effect on 5-HT-, histamine-, acetylcholine- and NA-induced contraction, and binding affinity for α2-adrenoceptor and dopamine D2-receptor. In vitro tests indicated that zwitter-ionization was capable of maintaining H1-antihistaminic activity while greatly reducing other pharmacological activities. Further, 6a-f showed much stronger inhibitory effects on compound 48/80-induced lethality in rats than did the corresponding N,N-dimethylamines (2a-f). 3-[N-[3-(6H-Dibenz[b,e]oxepin-11- ylidene)propyl]-N-methylamino]-propionic acid (6b-2), selected as a candidate antiallergic agent of a new type, equally potent in rats and guinea-pigs, exhibited strong inhibitory effects on 48 h homologous passive cutaneous anaphylaxis (PCA) in rats (ED50=0.019 mg/kg, p.o.) and on histamine- induced bronchoconstriction in anesthetized guinea-pigs (ED50=0.0067 mg/kg, p.o.).