162358-08-9Relevant articles and documents
A new efficient synthesis of the immunosuppressive agent FTY-720
Durand, Philippe,Peralba, Philippe,Sierra, Frederique,Renaut, Patrice
, p. 505 - 506 (2000)
A new efficient five-step synthesis of the immunosuppressive agent FTY- 720 is described.
PROCESS FOR PREPARATION OF FINGOLIMOD
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, (2015/02/18)
The present invention provides a process for preparation of fingolimod, a compound of Formula I or a pharmaceutically acceptable salt thereof, free of regioisomeric impurity compound of Formula IA
FINGOLIMOD HYDROCHLORIDE PROCESS
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, (2015/07/07)
A process for preparation of diethyl 2-acetamido-2-(4-octyl phenyl)ethyl malonate (III), a key intermediate of fingolimod hydrochloride comprising reaction of 2-(4- octylphenyl)ethyl iodide (IV) with diethyl acetamido malonate in presence of a base and an iodinating agent and in an organic solvent. The compound of formula (III) thus obtained provided fingolimod hydrochloride (la) having associated impurities below the regulatory limits.