162374-62-1

Basic information

• Product Name: Benzenamine, 4-(2-benzothiazolyl)-3-fluoro-
• CAS NO: 162374-62-1
• Molecular Formula: C13H9FN2S
• Molecular Weight: 244.292
• Mol File: 162374-62-1.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: Benzenamine, 4-(2-benzothiazolyl)-3-fluoro-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenamine, 4-(2-benzothiazolyl)-3-fluoro-(162374-62-1)
• EPA Substance Registry System: Benzenamine, 4-(2-benzothiazolyl)-3-fluoro-(162374-62-1)

Safety Data

• Hazardous Substances Data: 162374-62-1(Hazardous Substances Data)

Upstream product

• 446-31-1 2-fluoro-4-aminobenzoic acid 
• 137-07-5 2-amino-benzenethiol 
• 403-23-6 2-fluoro-4-nitrobenzoyl chloride 
• 162374-63-2 2-(2-Fluoro-4-nitrophenyl)benzothiazole 

Downstream Products

• 174536-72-2 Trifluoro-methanesulfonic acid 5-benzothiazol-2-yl-4-fluoro-2-(2,2,2-trifluoro-acetylamino)-phenyl ester 
• 174536-64-2 2-(4-Amino-2-fluoro-5-trifluoromethylsulfonyloxyphenyl)benzothiazole 
• 174536-69-7 2-(2-Fluoro-5-hydroxy-4-trifluoromethylsulfonamidophenyl)benzothiazole 
• 162374-64-3 2-(4-Azido-2-fluorophenyl)benzothiazole 

Relevant articles and documents

Substituted 2-arylbenzothiazoles as kinase inhibitors: Hit-to-lead optimization

Based on an (aminoaryl)benzothiazole quinazoline hit structure for kinase inhibition, a systematic optimization program resulted in a lead structure allowing for inhibitory activities in cellular phosphorylation assays in the low nanomolar range.

2-Arylbenzothiazole analogues and uses thereof in the treatment of cancer

The present invention relates to anticancer compounds of the general formula (I) and salts and physiologically functional derivatives thereof, wherein Y independently represents S, O, NR 2 , SO, SO 2 ; A independently represents a five- or six-membered aromatic carbocycle or heterocycle and wherein R 1 in formula (I) represents one of the heteroaryl groups defined in the claims.