1623775-05-2

Basic information

• Product Name: N-(2-[1-benzyl-1H-1,2,3-triazol-4-yl]propan-2-yl)benzamide
• Synonyms: N-(2-[1-benzyl-1H-1,2,3-triazol-4-yl]propan-2-yl)benzamide
• CAS NO: 1623775-05-2
• Molecular Weight: 320.394
• Mol File: 1623775-05-2.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: N-(2-[1-benzyl-1H-1,2,3-triazol-4-yl]propan-2-yl)benzamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2-[1-benzyl-1H-1,2,3-triazol-4-yl]propan-2-yl)benzamide(1623775-05-2)
• EPA Substance Registry System: N-(2-[1-benzyl-1H-1,2,3-triazol-4-yl]propan-2-yl)benzamide(1623775-05-2)

Safety Data

• Hazardous Substances Data: 1623775-05-2(Hazardous Substances Data)

Upstream product

• 622-79-7 benzyl azide 
• 2978-58-7 1,1-dimethylprop-3-ynylamine 
• 65-85-0 benzoic acid 
• 1623775-40-5 1-(1-benzyl-1H-1,2,3-triazol-4-yl)cyclohexan-1-amine 
• 98-88-4 benzoyl chloride 

Downstream Products

• 1623775-38-1 C₂₅H₂₀⁽²⁾H₄N₄O 
• 1623775-25-6 N-(2-[1-benzyl-1H-1,2,3-triazol-4-yl]propan-2-yl)-[1,1'-biphenyl]-2-carboxamide 
• 1646184-06-6 ethyl 2’-{(2-[1-benzyl-1H-1,2,3-triazol-4-yl]propan-2-yl)carbamoyl}1[1,1’-biphenyl]-4-carboxylate 
• 1646184-27-1 diethyl 2’-{(2-[1-benzyl-1H-1,2,3-triazol-4-yl]propan-2-yl)carbamoyl}-[1,1’:3’,1’’-terphenyl]-4,4’’-dicarboxylate 
• 118-90-1 ortho-methylbenzoic acid 

Relevant articles and documents

Iron-Catalyzed C?H Alkynylation through Triazole Assistance: Expedient Access to Bioactive Heterocycles

Triazole assistance enabled the first iron-catalyzed C?H alkynylation of arenes, heteroarenes, and alkenes. The modular TAM directing group set the stage for a sequential C?H alkynylation/annulation strategy with ample scope, enabling the iron-catalyzed assembly of isoquinolones, pyridones, pyrrolones, and isoindolinones with high levels of chemo-, site-, and regioselectivity.

Iron-catalyzed C(sp2)-H and C(sp3)-H arylation by triazole assistance

Modular 1,2,3-triazoles enabled iron-catalyzed C-H arylations with broad scope. The novel triazole-based bidentate auxiliary is easily accessible in a highly modular fashion and allowed for user-friendly iron-catalyzed C(sp 2)-H functionalizations of arenes and alkenes with excellent chemo- and diastereoselectivities. The versatile iron catalyst also proved applicable for challenging C(sp3)-H functionalizations, and proceeds by an organometallic mode of action. The triazole-assisted C-H activation strategy occurred under remarkably mild reaction conditions, and the auxiliary was easily removed in a traceless fashion. Intriguingly, the triazole group proved superior to previously used auxiliaries. With a little help: A versatile iron catalyst allows the arylation of C(sp2)-H and C(sp3)-H bonds in the presence of a modular and removable triazolyldimethylmethyl (TAM) auxiliary, whose structure can be varied through 1,3-dipolar azide-alkyne cycloadditions.