162402-39-3

Basic information

• Product Name: 4-(4-NITRO-PHENOXY)-PIPERIDINE
• Synonyms: 4-(4-NITRO-PHENOXY)-PIPERIDINE;4-(4-Nitrophenyloxy)piperidine;4-(4-Piperidinyl)oxy-1-nitrobenzene
• CAS NO: 162402-39-3
• Molecular Formula: C₁₁H₁₄N₂O₃
• Molecular Weight: 222.24
• EINECS: 604-604-1
• Mol File: 162402-39-3.mol
• Article Data: 11

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-(4-NITRO-PHENOXY)-PIPERIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(4-NITRO-PHENOXY)-PIPERIDINE(162402-39-3)
• EPA Substance Registry System: 4-(4-NITRO-PHENOXY)-PIPERIDINE(162402-39-3)

Safety Data

• Hazardous Substances Data: 162402-39-3(Hazardous Substances Data)

Usage

General Description

"4-(4-Nitro-phenoxy)-piperidine" is a chemical compound belonging to the class of organic compounds called piperidines. Piperidines are compounds containing a piperidine ring, which is a saturated aliphatic six-member ring with one nitrogen atom and five carbon atoms. The "4-nitro-phenoxy" in the name indicates, this piperidine is substituted with a nitrophenol ether group at the fourth position. This specific chemical is commonly used in the research and development phase in the pharmaceutical industry to make derivatives for potential drug candidates. However, it is deemed to be possibly hazardous, so it needs to be handled with appropriate safety measure due to its potential health risks such as skin and eye irritation and specific target organ toxicity.

Upstream product

• 138227-62-0 tert-butyl 4-(4-nitrophenoxy)piperidine-1-carboxylate 
• 100-02-7 4-nitro-phenol 
• 109384-19-2 t-butyl 4-hydroxy piperidine-1-carboxylate 
• 118811-07-7 tert-butyl 4-(tosyloxy)piperidin-1-carboxylate 
• 350-46-9 4-Fluoronitrobenzene 

Downstream Products

• 916905-62-9 4-(1-cyclobutylpiperidin-4-yloxy)-1-nitrobenzene 
• 862310-27-8 1-cyclopentyl -4-(4-nitrophenoxy)piperidine 
• 862314-14-5 1-cyclopropyl-4-(4-nitrophenoxy)piperidine 
• 1299487-08-3 1-(cyclopropylmethyl)-3-(4-(1-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)benzyl)piperidin-4-yloxy)phenyl)urea 
• 1299487-16-3 1-(4-(1-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)benzyl)piperidin-4-yloxy)phenyl)-3-(pyridin-4-yl)urea 
• 1299487-10-7 2-(4-((4-(4-aminophenoxy)piperidin-1-yl)methyl)phenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol 
• 1299487-09-4 1,1,1,3,3,3-hexafluoro-2-(4-((4-(4-nitrophenoxy)piperidin-1-yl)methyl)phenyl)propan-2-ol 
• 1637586-75-4 C₁₉H₁₆F₄N₂O₄ 
• 1637586-79-8 1-ethyl-3-(4-((1-(3-fluoro-4-(trifluoromethyl)benzoyl)piperidin-4-yl)oxy)phenyl)urea 
• 1637586-80-1 1-(2-chloroethyl)-3-(4-((1-(3-fluoro-4-(trifluoromethyl)benzoyl)piperidin-4-yl)oxy)phenyl)urea 
• 1637586-81-2 1-(4-((1-(3-fluoro-4-(trifluoromethyl)benzoyl)piperidin-4-yl)oxy)phenyl)imidazolidin-2-one 
• 1637586-82-3 1-ethyl-3-(4-((1-((4-fluorophenyl)sulfonyl)piperidin-4-yl)oxy)phenyl)urea 
• 1637586-77-6 (4-(4-aminophenoxy)piperidin-1-yl)(3-fluoro-4-(trifluoromethyl)phenyl)methanone 
• 1637586-78-7 4-((1-((4-fluorophenyl)sulfonyl)piperidin-4-yl)oxy)aniline 

Relevant articles and documents

Identification of N-phenyl-3-methoxy-4-pyridinones as orally bioavailable H3 receptor antagonists and β-amyloid aggregation inhibitors for the treatment of Alzheimer's disease

Based on our previous work, a series of N-phenyl-3-methoxy-4-pyridinone derivatives were designed as orally bioavailable dual functional agents for therapy of Alzheimer's disease, through introducing alkyloxy moiety into 4-pyridinone ring to avoid the pos

Synthesis and biological evaluation of novel urea-and guanidine-based derivatives for the treatment of obesity-related hepatic steatosis

Leptin, the product of the obese gene, is an adipocyte-secreted protein hormone playing a key role in the progression of obesity and hepatic steatosis. In this study, 28 novel (thio)urea and guanidine-based analogues have been synthesized and N-(1-(4-(3-(

Process for production of 4(3H)-quinazolinone derivative

The present invention provides a process for producing a 4(3H)-quinazolinone derivative, which is useful as a medicinal substance, with better efficiency in an industrial scale. The process comprises the steps of reacting 4-hydroxy-N-tert-butoxycarbonylpi