16249-03-9

Basic information

• Product Name: Acetophenon-p-nitrophenyl-semicarbazon
• CAS NO: 16249-03-9
• Molecular Weight: 298.301
• Mol File: 16249-03-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Acetophenon-p-nitrophenyl-semicarbazon(CAS DataBase Reference)
• NIST Chemistry Reference: Acetophenon-p-nitrophenyl-semicarbazon(16249-03-9)
• EPA Substance Registry System: Acetophenon-p-nitrophenyl-semicarbazon(16249-03-9)

Safety Data

• Hazardous Substances Data: 16249-03-9(Hazardous Substances Data)

Upstream product

• 17433-93-1 4-(4-nitrophenyl)semicarbazide 
• 98-86-2 acetophenone 
• 100-01-6 4-nitro-aniline 
• 556-10-5 p-nitrophenylurea 

Relevant articles and documents

Evaluation of semicarbazones for anticonvulsant and sedative-hypnotic properties

A series of semicarbazones and thiosemicarbazones were synthesized and evaluated for anti-convulsant activity. Some compounds provided significant protection against Maximal Electroshock (MES) and subcutaneous strychnine induced seizures. Compound 1 was the most active in the series with activity in a dose of 30 mg/kg in the strychnine seizure pattern test and an ED50 of 10 mg/kg in the MES test. Hence it could serve as a prototype molecule for future development. Also compounds with a p-nitrophenyl substitution in place of the amino hydrogen of semicarbazone moiety showed activity in a dose of 30 mg/kg and an ED50 of 83 mg/kg in the MES test.