162558-25-0 Usage
Description
N-Fmoc-N'-Boc-L-2,3-Diaminopropionic acid, also known as Boc-Dab(Fmoc)-OH, is a synthetic derivative of the naturally occurring non-proteinogenic amino acid L-2,3-Diaminopropionic acid. It is characterized by its white powder form and is commonly used in the field of organic chemistry and pharmaceuticals due to its unique chemical properties.
Uses
Used in Chemical Synthesis:
N-Fmoc-N'-Boc-L-2,3-Diaminopropionic acid is used as a building block for the synthesis of various complex organic molecules and pharmaceutical compounds. Its unique structure allows for the creation of diverse chemical entities with potential applications in drug development and other industries.
Used in Fluorescence Tagging:
As a lysine residue, its 3-amino group is often used for carrying a tag moiety such as a fluorescent dye. This allows for the tracking and visualization of specific molecules or biological processes in research and diagnostic applications.
Used in Quenching Applications:
The 3-amino group of N-Fmoc-N'-Boc-L-2,3-Diaminopropionic acid can also be used to carry a quencher moiety, which is essential in certain biochemical assays and fluorescence-based detection methods.
Used in Biotin Labeling:
N-Fmoc-N'-Boc-L-2,3-Diaminopropionic acid is used as a biotin labeling agent, enabling the specific recognition and detection of target molecules in various biological assays and diagnostic tests.
Used in the Pharmaceutical Industry:
N-Fmoc-N'-Boc-L-2,3-Diaminopropionic acid is used as an intermediate in the synthesis of various pharmaceutical compounds, contributing to the development of new drugs and therapies.
Used in the Research and Development Industry:
N-Fmoc-N'-Boc-L-2,3-Diaminopropionic acid is used as a research tool for studying the properties and interactions of amino acids, as well as for the development of new methodologies and techniques in organic chemistry and molecular biology.
Check Digit Verification of cas no
The CAS Registry Mumber 162558-25-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,6,2,5,5 and 8 respectively; the second part has 2 digits, 2 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 162558-25:
(8*1)+(7*6)+(6*2)+(5*5)+(4*5)+(3*8)+(2*2)+(1*5)=140
140 % 10 = 0
So 162558-25-0 is a valid CAS Registry Number.
InChI:InChI=1/C23H26N2O6/c1-23(2,3)31-21(28)24-12-19(20(26)27)25-22(29)30-13-18-16-10-6-4-8-14(16)15-9-5-7-11-17(15)18/h4-11,18-19H,12-13H2,1-3H3,(H,24,28)(H,25,29)(H,26,27)/t19-/m1/s1
162558-25-0Relevant articles and documents
Synthesis and opioid activity of conformationally constrained dynorphin A analogues. 1. Conformational constraint in the 'message' sequence
Arttamangkul,Murray,DeLander,Aldrich
, p. 2410 - 2417 (1995)
A constrained analogue of the opioid peptide dynorphin A (Dyn A) cyclized in the 'message' sequence was designed which may be compatible with the helical conformation proposed by Schwyzer (Biochemistry 1986, 25, 4281-4286) as the conformation Dyn A adopts
NITROGEN CONTAINING BICYCLIC COMPOUNDS AND THEIR USE IN TREATMENT OF BACTERIAL INFECTIONS
-
, (2017/01/23)
Compounds of Formula (I), their preparation, and use in preventing or treating a bacterial infection are disclosed.
A new approach to the neoglycopeptides: Synthesis of urea- and carbamate-tethered N-acetyl-D-glucosamine amino acid conjugates
Ichikawa, Yoshiyasu,Ohara, Fumiyo,Kotsuki, Hiyoshizo,Nakano, Keiji
, p. 5009 - 5012 (2007/10/03)
(Chemical Equation Presented) A novel approach to the synthesis of Fmoc-protected neoglycopeptide building blocks is described. Oxidation of N-acetyl-D-glucosamine isonitrile afforded the corresponding highly reactive glycopyranosyl isocyanate, which reacted with amino acid derivatives to furnish the corresponding urea- and carbamate-tethered Fmoc-protected N-acetyl-D-glucosamine amino acid conjugates in good yields.
Synthesis of alanine and proline amino acids with amino or guanidinium substitution on the side chain
Zhang, Zhenyu,Aerschot, Arthur Van,Hendrix, Chris,Busson, Roger,David, Frank,Sandra, Pat,Herdewijn, Piet
, p. 2513 - 2522 (2007/10/03)
Competitive binding of peptides containing basic amino acids to disrupt or prevent the Tat-TAR interaction could result in diminished transcription as well as translation and hence constitutes an alternative way of controlling HIV replication. Therefore, we synthesized guanidinium and amino containing amino acids, based on a proline or an alanine scaffold. The introduction of the guanidinium moiety was best accomplished using 1H- pyrazole-1-carboxamidine hydrochloride, with Pmc used for its protection. The absence of racemization, maintained throughout the whole synthesis, was confirmed by chiral purity determination. These building blocks were smoothly incorporated into oligopeptides, which proved their suitability for use in a combinatorial approach for selecting TAR binding ligands. (C) 2000 Elsevier Science Ltd.