16257-64-0 Usage
General Description
4-Hydroxy-1-(toluene-4-sulfonyl)-pyrrolidine-2-carboxylic acid is a chemical compound with the molecular formula C15H19NO5S. 4-HYDROXY-1-(TOLUENE-4-SULFONYL)-PYRROLIDINE-2-CARBOXYLIC ACID contains a pyrrolidine ring, a toluene-4-sulfonyl group, and a carboxylic acid group. It is a derivative of pyrrolidine and is used in the pharmaceutical industry as a building block in the synthesis of various drugs and potential bioactive compounds. This chemical may have applications in medicinal chemistry and drug development due to its structural features and potential biological activities. Its properties and uses make it an important molecule in the field of organic synthesis and drug discovery.
Check Digit Verification of cas no
The CAS Registry Mumber 16257-64-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,6,2,5 and 7 respectively; the second part has 2 digits, 6 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 16257-64:
(7*1)+(6*6)+(5*2)+(4*5)+(3*7)+(2*6)+(1*4)=110
110 % 10 = 0
So 16257-64-0 is a valid CAS Registry Number.
InChI:InChI=1/C12H15NO5S/c1-8-2-4-10(5-3-8)19(17,18)13-7-9(14)6-11(13)12(15)16/h2-5,9,11,14H,6-7H2,1H3,(H,15,16)
16257-64-0Relevant articles and documents
Synthesis, characterization and in vitro antitrypanosomal activities of new carboxamides bearing quinoline moiety
Ugwu, David Izuchukwu,Okoro, Uchechukwu Chris,Mishra, Narendra Kumar
, (2018/01/17)
The reported toxicities of current antitrypanosomal drugs and the emergence of drug resistant trypanosomes underscore the need for the development of new antitrypanosomal agents. We report herein the synthesis and antitrypanosomal activity of 24 new amide derivatives of 3-aminoquinoline, bearing substituted benzenesulphonamide. Nine of the new derivatives showed comparable antitrypanosomal activities at IC50 range of 1–6 nM (melarsoprol 5 nM). Compound 11n and 11v are more promising antitrypanosomal agents with IC50 1.0 nM than the rest of the reported derivatives. The novel compounds showed satisfactory predicted physico-chemical properties including oral bioavailability, permeability and transport properties.
