162611-62-3Relevant articles and documents
Two New Protecting Groups for the Guanidino Function of Arginine
Ali, Syed Safdar,Khan, Khalid Mohammed,Echner, Hartmut,Voelter, Wolfgang,Hasan, Mashooda,Atta-ur-Rahman
, p. 12 - 17 (2007/10/02)
Two new synthons, Fmoc-L-Arg(biphenyl-4-sulphonyl)-OH (8) and Fmoc-Arg(4-methoxy-3-t-butylbenzenesulphonyl)-OH (14), are prepared for the synthesis of arginine-containing peptides.These groups are cleaved by commonly employed trifluoroacetic acid and methanesulphonic acid.Kinetic studies reveal that extended bicyclic aromatic conjugation, as in biphenyl, slightly improves the acid lability compared to the electron-donating t-butyl group.