162611-87-2Relevant articles and documents
Rapid mild syntheses of [11C]benzophenones by Pd(0)-catalysed11C-carbonylative coupling of iodoarenes with phenyltributylstannane in DME-water
Al-Qahtani, Mohammed H.,Pike, Victor W.
, p. 825 - 835 (2000)
Palladium(0)-catalysed 11C-carbonylative coupling of iodoarenes (RC6H4I; R = H, 2-Me, 3-Me, 4-F, and 4-CF3) with phenyltributylstannane for 1 min in 1,2-dimethoxyethane-water (4: 1 v/v) at room temperature gave [11C]benzophenones (RC6H411COPh) in high radiochemical yields (58-82%. decay-corrected from trapped [11C]carbon monoxide). The efficiency of [11C]carbon monoxide trapping from a single pass into the reaction medium was 4.5-6.2%. The reaction conditions are suitable for the rapid, efficient introduction of cyclotron-produced carbon-11 (t1/2 = 20.3 min) into substituted benzophenones as prospective labelling agents and radiopharmaceuticals for application in medical imaging with positron emission tomography. Copyright
Palladium(II)-mediated 11C-carbonylative coupling of diaryliodonium salts with organostannanes-a new, mild and rapid synthesis of aryl [11C]ketones
Al-Qahtani, Mohammed H.,Pike, Victor W.
, p. 1033 - 1036 (2000)
Palladium(II)-mediated [11C]carbonylative coupling of diaryliodonium salts with aryltributylstannanes for 1 min in DME-water (4:1 v/v) at RT gives a new mild and rapid route to aryl [11C]ketones. Substituted aryltributylstannanes cou
Palladium-mediated [11C]carbonylation at atmospheric pressure: A general method using xantphos as supporting ligand
Dahl, Kenneth,Schou, Magnus,Amini, Nahid,Halldin, Christer
supporting information, p. 1228 - 1231 (2013/03/28)
The palladium-catalyzed [11C]carbonylation of aryl halides and triflates was achieved at atmospheric pressure by employing xantphos as the supporting ligand. Aryl halides were converted into their corresponding [ 11C]amides in good t
Synthesis of 11C-/13C-Ketones by Suzuki Coupling
Rahman, Obaidur,Kihlberg, Tor,Langstroem, Bengt
, p. 474 - 478 (2007/10/03)
Aryl triflates, methyl- or arylboronic acids, and a low concentration of [11C]carbon monoxide were employed on small scale in the syntheses of fifteen 11C-labelled ketones using palladium-mediated Suzuki coupling reactions. The reagents were confined in a micro-autoclave and heated at 150 °C for 5 min. The reaction required the presence of LiBr, but no additional base. The 11C-labelled products were obtained with decay-corrected radiochemical yields in the range 10-70% and with high specific radioactivity (150-640 GBq/μmol). The radiochemical purity of the final products exceeded 98%. One 13C-substituted ketone ([ 13C]-2′-benzonaphthone) was prepared and analysed by NMR spectroscopy for confirmation of the labelling position. The reference compound 2′-benzonaphthone was prepared by a palladium-catalysed reaction between sodium tetraphenylborate and 2-naphthoyl chloride. 2-Thienyl p-tolyl ketone, 4-nitrophenyl 2-thienyl ketone and 2-naphthyl 2-thienyl ketone were prepared by reactions between thiophene-2-boronic acid and the corresponding acid chlorides. The presented approach is novel and seems to be an efficient method for the synthesis of a wide range of 11C- as well as 13C-labelled ketones. Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004.
