162635-03-2 Usage
Description
Temsirolimus Acetonide, also known as Rapamycin 42-ester derivative, is a white gel-like chemical compound with potent immunosuppressive and antiproliferative properties. It is a derivative of the macrolide antibiotic Rapamycin, which is produced by the bacterium Streptomyces hygroscopicus. The compound has been found to be effective in inhibiting the activation and proliferation of T and B cells, making it a promising pharmaceutical candidate for various applications.
Uses
Used in Pharmaceutical Industry:
Temsirolimus Acetonide is used as an immunosuppressive agent for preventing organ transplant rejection and treating autoimmune diseases. It works by inhibiting the activation and proliferation of T and B cells, which play a crucial role in the immune response against transplanted organs and contribute to the pathology of autoimmune disorders.
Used in Anticancer Applications:
Temsirolimus Acetonide is employed as an anticancer agent, particularly against solid malignancies such as kidney, breast, and neuroendocrine tumors. It modulates several oncological signaling pathways, including the mTOR pathway, exerting inhibitory effects on tumor growth and progression. Additionally, it demonstrates synergistic anticancer effects when combined with conventional chemotherapeutic drugs, enhancing chemo-sensitivity and efficacy in resistant cases.
Used in Drug Delivery Systems:
To overcome the limitations of Temsirolimus Acetonide, such as poor solubility and bioavailability, novel drug delivery systems have been developed to enhance its applications and efficacy against cancer cells. Various organic and metallic nanoparticles, as well as liposomal formulations, have been employed as carriers for Temsirolimus Acetonide delivery, aiming to improve its pharmacokinetics, biodistribution, and therapeutic outcomes.
Check Digit Verification of cas no
The CAS Registry Mumber 162635-03-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,6,2,6,3 and 5 respectively; the second part has 2 digits, 0 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 162635-03:
(8*1)+(7*6)+(6*2)+(5*6)+(4*3)+(3*5)+(2*0)+(1*3)=122
122 % 10 = 2
So 162635-03-2 is a valid CAS Registry Number.
InChI:InChI=1/C59H91NO16/c1-35-19-15-14-16-20-36(2)47(69-11)31-43-24-22-41(7)59(68,76-43)53(64)54(65)60-26-18-17-21-44(60)55(66)74-48(32-45(61)37(3)28-40(6)51(63)52(71-13)50(62)39(5)27-35)38(4)29-42-23-25-46(49(30-42)70-12)75-56(67)58(10)33-72-57(8,9)73-34-58/h14-16,19-20,28,35,37-39,41-44,46-49,51-52,63,68H,17-18,21-27,29-34H2,1-13H3/b16-14+,19-15+,36-20+,40-28+/t35-,37-,38-,39-,41-,42+,43+,44+,46-,47+,48+,49-,51-,52+,59-/m1/s1
162635-03-2Relevant articles and documents
Method for separating and purifying temsirolimus
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Paragraph 0026; 0028, (2019/07/04)
The invention discloses a method for separating and purifying temsirolimus. The method comprises the following steps: (1) synthesis of a crude product; and (2) separation and purification. The specific separation and purification method has the advantages of great improvement of the purity and the yield of temsirolimus, reduction of the cost, and broad market application prospect.
Preparation method for temsirolimus
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Paragraph 0069; 0072-0074, (2019/01/08)
The invention provides a preparation method for temsirolimus. The preparation method comprises the following steps: step 1, dissolving 2,2,5-trimethyl-1,3-dioxane-5-carboxylic acid in a solvent underan alkaline condition, dropwise adding a solution of 2,4,6-trichlorobenzoyl chloride under stirring at a normal temperature, after a reaction is completed, carrying out cooling, adding a rapamycin double-protection compound, then dropwise adding an alkaline solution, and carrying out a reaction so as to obtain a coupled intermediate; and step 2, dissolving the coupled intermediate into a solvent,carrying out cooling, dropwise adding an inorganic acid solution, and carrying out deprotection so as to obtain the temsirolimus. The preparation method provided by the invention has the advantages ofsimple process, easy operation, high reaction yield, few by-products and applicability to industrial production.
REGIOSELECTIVE ACYLATION OF RAPAMYCIN AT THE C-42 POSITION
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Page/Page column 7-8, (2012/10/18)
The invention refers to the selective acylation of Rapamycin at the 42-position (I) with an acylating agent of the formula (II) wherein R4 and R5 are the same or different, individually the rest of an acetal, especially tetrahydropyran, or of a carbonate or the rest of a silyl ether or taken together are the rest of a boronate, an acetal or ketal.