162758-34-1Relevant articles and documents
The Synthesis and Pharmacological Evaluation of the Cannabinoid Antagonist SR 141716A
Dutta, Aloke K.,Sard, Howard,Ryan, William,Razdan, Raj K.,Compton, David R.,Martin, Billy R.
, p. 54 - 62 (2007/10/03)
The synthesis of the cannabinoid antagonist SR141716A is described from 4`-chloropropiophenone (1) in a four step sequence in an overall yield of 12 percent. The pharmacological results clearly demonstrate that SR141716A is able to antagonize the in vivo effects of the prototypical cannabinoid agonist Δ9-THC.