162758-94-3 Usage
Description
Dehydroepiandrosteron (DHEA) is a naturally occurring steroid hormone and a metabolic precursor to the primary sex hormones testosterone and estrogen. It is produced in the adrenal glands and plays a crucial role in the body's endocrine system. DHEA has been found to have various physiological effects, including anti-aging properties, immune system support, and potential neuroprotective benefits.
Uses
Used in Pharmaceutical Industry:
Dehydroepiandrosteron (DHEA) is used as a hormone supplement for its potential anti-aging effects and to support the body's natural production of testosterone and estrogen. It is believed to help improve muscle mass, bone density, and overall well-being in aging individuals.
Used in Neuroprotection:
DHEA is used as a neuroprotective agent for its ability to stimulate neurite growth, synaptogenesis, and glutamatergic synaptic activity in developing hippocampal neurons. It promotes neuronal differentiation of neural stem cells and supports the growth of cortical axons via modulation of hedgehog signaling.
Used in Anti-Inflammatory Applications:
Dehydroepiandrosteron (DHEA) is used as an anti-inflammatory agent for its ability to reduce LPS-induced TNFα production in cultured microglia cells and ameliorate LPS-induced neuroinflammation in a mouse model. This suggests its potential use in treating neuroinflammatory conditions and promoting overall brain health.
Used in Research:
DHEA is used as a research tool for studying the effects of steroid hormones on various physiological processes, including aging, immune function, and neuroprotection. It is also used to investigate the role of DHEA in modulating the orphan receptor GPR110, which may have implications for the development of new therapeutic strategies for various diseases.
References
1) Kim and Spector (2013),?Synaptamide, endocannabinoid-like derivative of docosahexaenoic acid with cannabinoid-independent function; Prostaglandins Leukot. Essent. Fatty Acids ,?88?121
2) Rashid?et al. (2013),?N-Docosahexaenoylethanolamide is a potent neurogenic factor for neural stem cell differentiation; J. Neurochem.,?125?869
3) Kharebava?et al.?(2015),?N-docosahexaenoylethanolamine regulates Hedgehog signaling and promotes growth of cortical axons; Biol. Open.,?4?1660
4) Lee?et al. (2016),?Orphan GPR110 (ADGRF1) targeted by N-docosahexaenoylethanolamine in development of neurons and cognitive function; Nat. Commun.,?7?13123
5) Park?et al. (2016),?N-docosahexaenoylethanolamine ameliorates LPS-induced neuroinflammation via cAMP/PKA-dependent signaling; J. Neuroinflammation,?13?284
Check Digit Verification of cas no
The CAS Registry Mumber 162758-94-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,6,2,7,5 and 8 respectively; the second part has 2 digits, 9 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 162758-94:
(8*1)+(7*6)+(6*2)+(5*7)+(4*5)+(3*8)+(2*9)+(1*4)=163
163 % 10 = 3
So 162758-94-3 is a valid CAS Registry Number.
162758-94-3Relevant articles and documents
One-pot synthesis of polyunsaturated fatty acid amides with anti-proliferative properties
Tremblay, Hugo,St-Georges, Catherine,Legault, Marc-Andr,Morin, Caroline,Fortin, Samuel,Marsault, Eric
, p. 5635 - 5638 (2015/01/09)
A one-pot environmentally friendly transamidation of ω-3 fatty acid ethyl esters to amides and mono- or diacylglycerols was investigated via the use of a polymer-supported lipase. The method was used to synthesize a library of fatty acid monoglyceryl esters and amides. These new derivatives were found to have potent growth inhibition effects against A549 lung cancer cells.
