1627749-02-3Relevant articles and documents
Novel methyl substituted 1-(5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)methanones are P2X7 antagonists
Rudolph, Dale A.,Alcazar, Jesus,Ameriks, Michael K.,Anton, Ana Belen,Ao, Hong,Bonaventure, Pascal,Carruthers, Nicholas I.,Chrovian, Christa C.,De Angelis, Meri,Lord, Brian,Rech, Jason C.,Wang, Qi,Bhattacharya, Anindya,Andres, Jose Ignacio,Letavic, Michael A.
, p. 3157 - 3163 (2015)
Abstract The optimization efforts that led to a novel series of methyl substituted 1-(5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)methanones that are potent rat and human P2X7 antagonists are described. These efforts resulted in the discovery of co
N - acyl - [...] P 2X7 adjustment
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, (2017/10/28)
The present invention is directed to compounds of Formula (I), which includes enantiomer and diasteromers thereof: These compounds are suitable for use in the treatment of diseases associated with P2X7 receptor activity such as diseases of the autoimmune
P2X7 MODULATORS
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Paragraph 0126; 0360, (2014/09/30)
The present invention is directed to a compound of Formula (I) and to pharmaceutical compositions comprising compounds of Formula (I). Methods of making and using the compounds of Formula (I) are also within the scope of the invention.