1629243-84-0Relevant articles and documents
Efficient catalyst-free one-pot three-component synthesis of novel spirooxindole derivatives, and their cytotoxic activities
Han, Chao,Zhang, Tao,Zhang, Anqi,Wang, Dandan,Shi, Weimin,Tao, Jingchao
, p. 1389 - 1398 (2014/06/09)
A simple and efficient one-pot approach for assembling novel spiro[indolepyranopyrrole] derivatives was developed and used to prepare a series of biologically important compounds. The reaction was easily performed with high efficiency under very simple and mild conditions without any catalysts and it gave good yields, avoiding time-consuming costly synthesis and laborious workup and purification of products. The cytotoxic activities of these new spiro[indolepyranopyrrole] derivatives were evaluated in vitro. Most of the tested compounds exhibited significant cytotoxicities to Raji cell lines. Georg Thieme Verlag Stuttgart New York.