162936-24-5 Usage
Description
2-IODO-5'-ETHYLCARBOXAMIDO-2',3'-O-ISOPROPYLIDINEADENOSINE, with the CAS number 162936-24-5, is an off-white solid compound that is useful in organic synthesis. It is a modified adenosine derivative with a unique structure that includes an ethylcarboxamido group at the 5' position and an isopropylidine bridge between the 2' and 3' positions.
Uses
Used in Organic Synthesis:
2-IODO-5'-ETHYLCARBOXAMIDO-2',3'-O-ISOPROPYLIDINEADENOSINE is used as a synthetic intermediate for the preparation of various organic compounds. Its unique structure allows for the formation of new chemical bonds and the synthesis of complex molecules with potential applications in various fields.
Used in Pharmaceutical Industry:
2-IODO-5'-ETHYLCARBOXAMIDO-2',3'-O-ISOPROPYLIDINEADENOSINE is used as a building block for the development of new pharmaceutical compounds. Its adenosine-like structure and unique modifications make it a promising candidate for the design of novel drugs with potential therapeutic applications.
Used in Chemical Research:
2-IODO-5'-ETHYLCARBOXAMIDO-2',3'-O-ISOPROPYLIDINEADENOSINE is used as a research tool in chemical studies. Its unique properties and reactivity can provide insights into the behavior of similar compounds and contribute to the advancement of chemical knowledge and techniques.
Check Digit Verification of cas no
The CAS Registry Mumber 162936-24-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,6,2,9,3 and 6 respectively; the second part has 2 digits, 2 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 162936-24:
(8*1)+(7*6)+(6*2)+(5*9)+(4*3)+(3*6)+(2*2)+(1*4)=145
145 % 10 = 5
So 162936-24-5 is a valid CAS Registry Number.
162936-24-5Relevant articles and documents
Linear and convergent approaches to 2-substituted adenosine-5′-N-alkylcarboxamides
Foitzik, Richard C.,Devine, Shane M.,Hausler, Nicholas E.,Scammells, Peter J.
experimental part, p. 8851 - 8857 (2009/12/26)
Herein we report both linear and convergent pathways for the preparation of 2-alkynyl substituted adenosine-5′-N-ethylcarboxamides via the versatile synthetic intermediate, 2-iodoadenosine-5′-N-ethylcarboxamide (13). The linear approach afforded 13 in an overall yield of 30% from guanosine over eight synthetic steps. The convergent approach was shorter, but proceeded in lower yield (five steps, 20% yield). Both approaches compare favourably with previously reported syntheses of 13, which has been prepared in 15% yield from guanosine over nine steps. 2-Iodoadenosine-5′-N-ethylcarboxamide (13) was subsequently converted to HENECA (2) and PHPNECA (3) to exemplify the utility of this approach for the preparation of?potent A2A adenosine receptor agonists. The linear approach was also amenable to the synthesis of 2-fluoropurine ribosides, which were subsequently elaborated into 2-alkylaminoadenosine-5′-N-ethylcarboxamides. Furthermore, both of these synthetic approaches are readily amenable to the synthesis of adenosine analogues with varied 2-, 6- and 5′-substitution patterns.
METHODS FOR PREPARING 2-ALKYNYLADENOSINE DERIVATIVES
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Page 18; 32, (2010/02/09)
Disclosed are methods for preparing 2-alkynyladenosine derivatives of Formula (A): or a stereoisomer, pharmaceutically acceptable salt, hydrate, solvate, acid salt hydrate or isomorphic crystalline form thereof, the method comprising the step ofcontacting
