16297-01-1

Basic information

• Product Name: 2,4,6-trihydroxy-5-methoxyacetophenone
• Synonyms: 2,4,6-trihydroxy-5-methoxyacetophenone
• CAS NO: 16297-01-1
• Molecular Weight: 198.175
• Mol File: 16297-01-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2,4,6-trihydroxy-5-methoxyacetophenone(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4,6-trihydroxy-5-methoxyacetophenone(16297-01-1)
• EPA Substance Registry System: 2,4,6-trihydroxy-5-methoxyacetophenone(16297-01-1)

Safety Data

• Hazardous Substances Data: 16297-01-1(Hazardous Substances Data)

Upstream product

• 487-71-8 Iretol 
• 75-05-8 acetonitrile 
• 108-24-7 acetic anhydride 
• 487-70-7 2,4,6-trihydroxybenzaldehyde 
• 212265-19-5 2,4,6-tris(O-methoxymethyl)benzaldehyde 

Downstream Products

• 1447-88-7 hispidulin 

Relevant articles and documents

Total Synthesis of Hispidulin and the Structural Basis for Its Inhibition of Proto-oncogene Kinase Pim-1

(Figure Presented). A new method is applied to synthesize hispidulin, a natural flavone with a broad spectrum of biological activities. Hispidulin exhibits inhibitory activity against the oncogenic protein kinase Pim-1. Crystallographic analysis of Pim-1 bound to hispidulin reveals a binding mode distinct from that of quercetin, suggesting that the binding potency of flavonoids is determined by their hydrogen-bonding interactions with the hinge region of the kinase. Overall, this work may facilitate construction of a library of hispidulin-derived compounds for investigating the structure-activity relationship of flavone-based Pim-1 inhibitors.