16297-07-7 Usage
Description
2,3,5,6-Tetrafluoro-4-pyridinecarbonitrile, also known as tetrafluoro-4-cyanopyridine or 4-cyanotetrafluoropyridine, is a perfluorinated heteroaromatic compound with unique chemical properties. It features a pyridine ring with four fluorine atoms at the 2, 3, 5, and 6 positions, and a nitrile group at the 4 position. 2,3,5,6-TETRAFLUORO-4-PYRIDINE-CARBONITRILE is known for its reactivity with various nucleophiles and its ability to participate in cyclization reactions, making it a valuable intermediate in the synthesis of various organic compounds.
Uses
Used in Pharmaceutical Industry:
2,3,5,6-Tetrafluoro-4-pyridinecarbonitrile is used as a key intermediate in the synthesis of 2-anilino-3,5,6-trifluoroisonicotinonitrile, which is an important compound in the development of pharmaceuticals. The unique properties of this perfluorinated heteroaromatic compound enable the creation of new drug candidates with potential therapeutic applications.
Used in Organic Synthesis:
In the field of organic synthesis, 2,3,5,6-tetrafluoro-4-pyridinecarbonitrile serves as a versatile building block for the preparation of various heterocyclic compounds. Its reactivity with 1,3-dicarbonyl systems allows for the formation of [5,6]-ring fused furo derivatives, while its reaction with amidines leads to the synthesis of [6,6]-fused pyrimidinopyridine systems through nucleophilic substitution and intramolecular cyclization. Additionally, its reaction with sulfur-centered nucleophiles has been reported, further expanding its utility in organic chemistry.
Overall, 2,3,5,6-tetrafluoro-4-pyridinecarbonitrile is a valuable perfluorinated heteroaromatic compound with diverse applications in the pharmaceutical industry and organic synthesis, making it an important compound for the development of new drugs and organic compounds.
Check Digit Verification of cas no
The CAS Registry Mumber 16297-07-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,6,2,9 and 7 respectively; the second part has 2 digits, 0 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 16297-07:
(7*1)+(6*6)+(5*2)+(4*9)+(3*7)+(2*0)+(1*7)=117
117 % 10 = 7
So 16297-07-7 is a valid CAS Registry Number.
InChI:InChI=1/C6F4N2/c7-3-2(1-11)4(8)6(10)12-5(3)9
16297-07-7Relevant articles and documents
Organocatalyzed Fluoride Metathesis
Mulryan, Daniel,White, Andrew J. P.,Crimmin, Mark R.
supporting information, p. 9351 - 9355 (2020/11/30)
A new organocatalyzed fluoride metathesis reaction between fluoroarenes and carbonyl derivatives is reported. The reaction exchanges fluoride (F-) and alternate nucleophiles (OAc-, OCO2R-, SR-, Cl-, CN-, NCS-). The approach provides a conceptually novel route to manipulate the fluorine content of organic molecules. When the fluorination and defluorination steps are combined into a single catalytic cycle, a byproduct free and 100% atom-efficient reaction can be achieved.