1630-35-9

Basic information

• Product Name: (1R,2S)-N-<(2-Hydroxy-2-phenyl)-1-methyl-ethyl>-N-methylformamid
• Synonyms: (1R,2S)-N-<(2-Hydroxy-2-phenyl)-1-methyl-ethyl>-N-methylformamid
• CAS NO: 1630-35-9
• Molecular Weight: 193.246
• Mol File: 1630-35-9.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: (1R,2S)-N-<(2-Hydroxy-2-phenyl)-1-methyl-ethyl>-N-methylformamid(CAS DataBase Reference)
• NIST Chemistry Reference: (1R,2S)-N-<(2-Hydroxy-2-phenyl)-1-methyl-ethyl>-N-methylformamid(1630-35-9)
• EPA Substance Registry System: (1R,2S)-N-<(2-Hydroxy-2-phenyl)-1-methyl-ethyl>-N-methylformamid(1630-35-9)

Safety Data

• Hazardous Substances Data: 1630-35-9(Hazardous Substances Data)

Upstream product

• 299-42-3 ephedrine 
• 109-94-4 formic acid ethyl ester 
• 72179-93-2 aminomethylene-malonic acid dimethyl ester 
• 4637-24-5 N,N-dimethyl-formamide dimethyl acetal 
• 111333-97-2 formic acid pentafluorophenyl ester 

Downstream Products

• 26343-75-9 N-formylmethamphetamine 
• 145388-34-7 (2S)-2-<2-(Dimethylamino)propyl>-N,N-dimethylphenylacetamide 
• 145388-35-8 (2S)-1-<2-(2-Dimethylaminoethyl)phenyl>-N,N-dimethyl-2-propanamin 
• 552-79-4 (-)-N-methylephedrine 
• 145388-33-6 (2S)-2-<2-(Acetyl-methyl-amino)propyl>-N,N-dimethylphenylformamid 

Relevant articles and documents

A novel type of N-formylation and related reactions of amines via cyanides and esters as formylating agents

A novel N-formylation and related reactions proceed from cyanides promoted by esters. The Royal Society of Chemistry.

Reactions of (-)-Ephedrine, (+)-Norpseudoephedrine and Derivatives with N,N-Dimethylacetamid-dimethylacetal and N,N-Dimethylformamid-dimethylacetal

The reactivity of (-)-ephedrine (2) and (+)-norpseudoephedrine (3) towards the amid-acetals 1 a/b has been studied.Both 2 and 3 were acetylated resp. formylated at first at the amino group.Nevertheless, derivatives of 2 and 3 possessing a trisubstituted amino group react with 1 a in a sigmatropic rearrangement to ortho substituted dimethylcarbamoylmethyl derivatives.By subsequent reduction with lithiumaluminiumhydride the aromatic compounds 8, 13, and 18 with two aminoethyl groups are easily available.In contrast to these results 1 b did not furnish any rearrangement products. Keywords. (-)-Ephedrine; (+)-Norpseudoephedrine; N,N-Dimethylacetamid-dimethylacetal; N,N-Dimethylformamid-dimethylacetal; Sympathomimetic effects; Sigmatropic rearrangements.