16304-39-5

Basic information

• Product Name: 5-hydroxybenzo[b]thiophene-3-carboxylic acid
• Synonyms: 5-hydroxybenzo[b]thiophene-3-carboxylic acid;5-Hydroxy-1-benzothiophene-3-carboxylic acid
• CAS NO: 16304-39-5
• Molecular Formula: C₉H₆O₃S
• Molecular Weight: 194.20714
• Mol File: 16304-39-5.mol
• Article Data: 5

Chemical Properties

• Melting Point: 264-265℃
• Appearance: /
• Density: 1.566
• Storage Temp.: 2-8°C(protect from light)
• CAS DataBase Reference: 5-hydroxybenzo[b]thiophene-3-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 5-hydroxybenzo[b]thiophene-3-carboxylic acid(16304-39-5)
• EPA Substance Registry System: 5-hydroxybenzo[b]thiophene-3-carboxylic acid(16304-39-5)

Safety Data

• Hazardous Substances Data: 16304-39-5(Hazardous Substances Data)

Usage

Description

5-Hydroxybenzo[b]thiophene-3-carboxylic acid is an organic compound characterized by the presence of a hydroxyl group attached to a benzothiophene ring and a carboxylic acid group. It is known for its unique chemical structure and potential applications in various fields.

Uses

Used in Pharmaceutical Industry:
5-Hydroxybenzo[b]thiophene-3-carboxylic acid is used as a reactant in the synthesis of derivatives of prostaglandin D2 receptor antagonists with a 6,6-dimethylbicyclo[3.1.1]heptane skeleton. These derivatives have potential applications in the development of antiallergic drugs, as they can help modulate the immune response and alleviate allergic symptoms.
Additionally, due to its chemical structure, 5-hydroxybenzo[b]thiophene-3-carboxylic acid may also be utilized in the synthesis of other bioactive compounds, contributing to the advancement of pharmaceutical research and drug development.

Upstream product

• 90920-99-3 methyl 5-hydroxybenzo[b]thiophene-3-carboxylate 
• 4923-87-9 5-bromobenzo[b]thiophene 
• 1423-63-8 1-(5-bromobenzo[b]thiophen-3-yl)ethan-1-one 
• 118780-12-4 1-bromo-4-[2,2-(dimethoxy)ethylsulfanyl]benzene 
• 106-53-6 para-bromobenzenethiol 
• 123392-43-8 5-methoxy-3-benzo[b]thiophenecarboxylic acid 
• 7312-24-5 5-bromobenzo[b]thiophene-3-carboxylic acid 
• 209268-25-7 5-benzenesulfonyloxybenzo[b]thiophene-3-carboxylic acid 

Downstream Products

• 209268-27-9 5-benzenesulfonyloxybenzo[b]thiophene-3-carbonyl chloride 

Relevant articles and documents

Process for the preparation of pgd2 antagonist

The present invention provides an efficient process for the preparation of benzothiophenecarboxamide PGD2 antagonist, S-5751.

Process for preparing 5-hydroxybenzo [b] thiophene-3-carboxylic acid derivatives

Processes for producing compounds of the formula (VI) are disclosed. Benzothiophenecarboxylic acid derivatives of the formula (I), which are useful as starting materials for producing drugs, are disclosed. Particularly, disclosed is a process for preparin

Benzothiophenecarboxamide derivatives and PGD2 antagonists comprising them

PCT No. PCT/JP97/04527 Sec. 371 Date May 17, 1999 Sec. 102(e) Date May 17, 1999 PCT Filed Dec. 10, 1997 PCT Pub. No. WO98/25919 PCT Pub. Date Jun. 18, 1998A compound, a pharmaceutically acceptable salt thereof, or a hydrate thereof having PGD2-antagonisti