163041-70-1

Basic information

• Product Name: C₂₆H₃₀O₆
• Synonyms: C₂₆H₃₀O₆
• CAS NO: 163041-70-1
• Molecular Weight: 438.521
• Mol File: 163041-70-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₆H₃₀O₆(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₆H₃₀O₆(163041-70-1)
• EPA Substance Registry System: C₂₆H₃₀O₆(163041-70-1)

Safety Data

• Hazardous Substances Data: 163041-70-1(Hazardous Substances Data)

Upstream product

• 16162-69-9 1-(4-(tetrahydro-2H-pyran-2-yloxy)phenyl)ethanone 
• 163041-68-7 2-methoxy-4-((tetrahydro-2H-pyran-2-yl)oxy)benzaldehyde 

Downstream Products

• 34221-41-5 Echinatin 

Relevant articles and documents

Synthesis and topoisomerase II inhibitory and cytotoxic activity of oxiranylmethoxy- and thiiranylmethoxy-chalcone derivatives

In order to find potential anticancer drug candidate targeting topoisomerases enzyme, we have designed and synthesized oxiranylmethoxy- and thiiranylmethoxy-retrochalcone derivatives and evaluated their pharmacological activity including topoisomerases inhibitory and cytotoxic activity. Of the compounds prepared compound 25 showed comparable or better cytotoxic activity against cancer cell lines tested. Compound 25 inhibited MCF7 (IC50: 0.49 ± 0.21 μM) and HCT15 (IC50: 0.23 ± 0.02 μM) carcinoma cell growth more efficiently than references. In the topoisomerases inhibition test, all the compounds were inactive to topoisomerase I but moderate inhibitors to topoisomerase II enzyme. Especially, compound 25 inhibited topoisomerase II activity with comparable extent to etoposide at 100 μM concentrations. Correlation between cytotoxicity and topoisomerase II inhibitory activity implies that compound 25 can be a possible lead compound for anticancer drug impeding the topoisomerase II function.