16305-78-5

Basic information

• Product Name: benzyl N-[(benzyloxy)carbonyl]alanylglycinate
• CAS NO: 16305-78-5
• Molecular Formula: C₂₀H₂₂N₂O₅
• Molecular Weight: 370.3991
• Mol File: 16305-78-5.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 581.5°C at 760 mmHg
• Flash Point: 305.5°C
• Density: 1.218g/cm³
• Vapor Pressure: 1.63E-13mmHg at 25°C
• Refractive Index: 1.563
• CAS DataBase Reference: benzyl N-[(benzyloxy)carbonyl]alanylglycinate(CAS DataBase Reference)
• NIST Chemistry Reference: benzyl N-[(benzyloxy)carbonyl]alanylglycinate(16305-78-5)
• EPA Substance Registry System: benzyl N-[(benzyloxy)carbonyl]alanylglycinate(16305-78-5)

Safety Data

• Hazardous Substances Data: 16305-78-5(Hazardous Substances Data)

Upstream product

• 17350-66-2 N-benzyloxycarbonylalaninehydrazid 
• 1738-68-7 Gly-OBz 
• 1142-20-7 N-Cbz-Ala 
• 1738-76-7 glycine benzyl ester p-toluenesulfonic acid salt 
• 76413-56-4 3-(N-benzyloxycarbonyl-L-alanyl)-1,3-thiazolidine-2-thione 
• 122751-37-5 Z-Ala-OPyCl 
• 81650-35-3 Z-Alat-Gly-OBzl 
• 2462-31-9 benzyl 2-aminoacetate hydrochloride 
• 25172-67-2 Z-Ala-O-COO-isoBu 

Downstream Products

• 687-69-4 alanylglycine 
• 81650-35-3 Z-Alat-Gly-OBzl 

Relevant articles and documents

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1-(o-NITROPHENYLSULPHONYLOXY)BENZOTRIAZOLE, REAGENT FOR THE CONDENSATION OF CARBOXYLIC ACIDS WITH AMINES

With the Schotten-Baumann reaction we have synthesized 1-(o-nitrophenylsulfonyloxy)benzotriazole and have shown its suitability for the synthesis of esters of 1-hydroxybenzotriazole and carboxylic amides, and also of peptides.

STUDIES ON AMINO ACIDS AND PEPTIDES-I SYNTHESIS OF N-BENZYLOXYCARBONYLENDOTHIODIPEPTIDE ESTERS

N-Benzyloxycarbonylendothiodipeptide esters, 3, are synthesized without racemization from the corresponding N-benzyloxycarbonyldipeptide esters, 2, using 2,4-bis(4-methoxyphenyl)-1,3,2,4-dithiadiphosphetane 2,4-disulfide, 1, as thionation reagent.The benzyloxycarbonyl amino-protecting group (Z) is removed from 3 by using HBr-AcOH.