1630973-79-3

Basic information

• Product Name: methyl 5-((4R,5R)-4-(ethoxycarbonyl)-1-(2-hydroxyphenyl)-5-methyl-4,5-dihydro-1H-imidazol-5-yl)oxazole-4-carboxylate
• CAS NO: 1630973-79-3
• Molecular Weight: 359.338
• Mol File: 1630973-79-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: methyl 5-((4R,5R)-4-(ethoxycarbonyl)-1-(2-hydroxyphenyl)-5-methyl-4,5-dihydro-1H-imidazol-5-yl)oxazole-4-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 5-((4R,5R)-4-(ethoxycarbonyl)-1-(2-hydroxyphenyl)-5-methyl-4,5-dihydro-1H-imidazol-5-yl)oxazole-4-carboxylate(1630973-79-3)
• EPA Substance Registry System: methyl 5-((4R,5R)-4-(ethoxycarbonyl)-1-(2-hydroxyphenyl)-5-methyl-4,5-dihydro-1H-imidazol-5-yl)oxazole-4-carboxylate(1630973-79-3)

Safety Data

• Hazardous Substances Data: 1630973-79-3(Hazardous Substances Data)

Upstream product

• 7653-60-3 3-methyl-1,4-benzoxazin-2-one 
• 39687-95-1 isocyanoacetic acid methyl ester 

Relevant articles and documents

Highly diastereo- and enantioselective silver-catalyzed double [3+2] cyclization of α-imino esters with isocyanoacetate

Presented herein is a new complexity-generating method in which both functionalities of α-imino esters undergo stereoselective cyclization with isocyanoacetates to produce directly linked oxazole-imidazolines, which can be transformed into highly functionalized α,β-diamino esters and imidazolinium salts in high diastereo- and enantiopurity. Double up: An unprecedented silver-catalyzed title reaction has been developed and provides access to directly linked oxazole-imidazolines. A highly diastereo- and enantioselective variant was also realized using the catalyst Ag/L*. The products can be easily transformed into highly functionalized chiral α,β-diamino esters or imidazolinium salts which are useful motifs in asymmetric synthesis and catalysis.