1631035-62-5

Basic information

• Product Name: 1-(1-fluoro-3-phenylpropyl)-4-methylbenzene
• Synonyms: 1-(1-fluoro-3-phenylpropyl)-4-methylbenzene
• CAS NO: 1631035-62-5
• Molecular Weight: 228.309
• Mol File: 1631035-62-5.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 1-(1-fluoro-3-phenylpropyl)-4-methylbenzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(1-fluoro-3-phenylpropyl)-4-methylbenzene(1631035-62-5)
• EPA Substance Registry System: 1-(1-fluoro-3-phenylpropyl)-4-methylbenzene(1631035-62-5)

Safety Data

• Hazardous Substances Data: 1631035-62-5(Hazardous Substances Data)

Upstream product

• 624-31-7 4-tolyl iodide 
• 62056-37-5 1-methyl-4-[(1E)-3-phenylprop-1-en-1-yl]benzene 
• 122058-30-4 p-methylcinnamyl alcohol 
• 98-80-6 phenylboronic acid 

Relevant articles and documents

Nickel-Catalyzed Reductive Cross-Coupling of Aryl Halides with Monofluoroalkyl Halides for Late-Stage Monofluoroalkylation

A combinatorial nickel-catalyzed monofluoroalkylation of aryl halides with unactivated fluoroalkyl halides by reductive cross-coupling has been developed. This method demonstrated high efficiency, mild conditions, and excellent functional-group tolerance, thus enabling the late-stage monofluoroalkylation of diverse drugs. The key to success was the combination of diverse readily available bidentate and monodentate pyridine-type nitrogen ligands with nickel, which in situ generated a variety of readily tunable catalysts to promote fluoroalkylation with broad scope with respect to both coupling partners. This combinatorial catalysis strategy offers a solution for nickel-catalyzed reductive cross-coupling reactions and provides an efficient way to synthesize fluoroalkylated druglike molecules for drug discovery.