163232-53-9

Basic information

• Product Name: C₁₈H₁₂ClNO₃
• Synonyms: C₁₈H₁₂ClNO₃
• CAS NO: 163232-53-9
• Molecular Weight: 325.751
• Mol File: 163232-53-9.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: C₁₈H₁₂ClNO₃(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₈H₁₂ClNO₃(163232-53-9)
• EPA Substance Registry System: C₁₈H₁₂ClNO₃(163232-53-9)

Safety Data

• Hazardous Substances Data: 163232-53-9(Hazardous Substances Data)

Upstream product

• 134-20-3 2-carbomethoxyaniline 
• 81937-41-9 Methyl N-acetoacetylanthranilate 
• 26138-64-7 4-hydroxy-3-acetyl-1H-quinoline-2-one 
• 104-88-1 4-chlorobenzaldehyde 

Relevant articles and documents

L-Proline as an efficient catalyst for synthesis of N-heterocyclic chalcones as potential antibacterial agents

The condensation of 4-hydroxy-3-acetyl-1H-quinoline-2-one 1 and substitutedbenzaldehydes 2a-i in DMSO solution at room temperature yields quinolone chalcone derivatives 3a-i. L-Proline has been found to be an efficient catalyst for this condensation between 1 and 2. Only 5 mol% of the catalyst is necessary to achieve good yields of the products. Reactions proceed smoothly with variations of the substituents. 1 itself is synthesized by the acylation of commercially available methyl anthranilate 4 with acetoacetic ester 5 in refluxing xylene and subsequent Dieckman intramolcular cyclization of the intermediary 2-methoxycarbonylanilide 6.