1632485-14-3

Basic information

• Product Name: 2,5-Dichloro-N-[2-[(1-methylethyl)thio]phenyl]-4-pyrimidinamine
• Synonyms: 2,5-Dichloro-N-[2-[(1-methylethyl)thio]phenyl]-4-pyrimidinamine
• CAS NO: 1632485-14-3
• Molecular Formula: C13H13Cl2N3S
• Molecular Weight: 314.23342
• Mol File: 1632485-14-3.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 443.9±40.0 °C(Predicted)
• Appearance: /
• Density: 1.37±0.1 g/cm3(Predicted)
• PKA: 0.35±0.10(Predicted)
• CAS DataBase Reference: 2,5-Dichloro-N-[2-[(1-methylethyl)thio]phenyl]-4-pyrimidinamine(CAS DataBase Reference)
• NIST Chemistry Reference: 2,5-Dichloro-N-[2-[(1-methylethyl)thio]phenyl]-4-pyrimidinamine(1632485-14-3)
• EPA Substance Registry System: 2,5-Dichloro-N-[2-[(1-methylethyl)thio]phenyl]-4-pyrimidinamine(1632485-14-3)

Safety Data

• Hazardous Substances Data: 1632485-14-3(Hazardous Substances Data)

Usage

General Description

2,5-Dichloro-N-[2-[(1-methylethyl)thio]phenyl]-4-pyrimidinamine is a chemical compound with the molecular formula C13H13Cl2N3S. It is a pyrimidine-based herbicide that is used to control weeds in various agricultural and industrial settings. The compound works by inhibiting the growth of undesirable plants through interference with their cellular processes. It is typically applied as a spray or in granular form and is effective against a wide range of broadleaf and grassy weeds. The compound is considered to have low toxicity towards humans and animals when used according to recommended guidelines, but caution should be exercised in handling and application to minimize potential exposure.

Upstream product

• 137-07-5 2-amino-benzenethiol 
• 6397-33-7 2-aminophenyl isopropyl sulphide 
• 5750-76-5 2,4,5-trichloropyrimidine 
• 1493-27-2 ortho-nitrofluorobenzene 
• 70415-85-9 2-(isopropyl sulfanyl)nitrobenzene 
• 3764-01-0 2,4,6-trichloropyrimidine 
• 861343-73-9 2-(isopropylthioether)aniline hydrochloride 

Downstream Products

• 1346447-79-7 5-chloro-N⁴-(2-(isopropylsulfonyl)phenyl)-N²-(3-nitrophenyl)pyrimidine-2,4-diamine 
• 1346447-80-0 5-chloro-4-N-(2-isopropylsulfonylbenzene)-2-N-(3-aminophenyl)pyrimidine-2,4-diamine 

Relevant articles and documents

CHEMICAL PROCESS FOR PREPARING PYRIMIDINE DERIVATIVES AND INTERMEDIATES THEREOF

PROBLEM TO BE SOLVED: To provide a process for preparing ceritinib and/or intermediates thereof. SOLUTION: There is provided a process for preparing (C2-1), an intermediate of ceritinib synthesis, comprising the step of reacting (A) with (B) in a solvent in the presence of at least one catalyst, wherein P is a protecting group and T and X1 independently denote Cl and the like. SELECTED DRAWING: None COPYRIGHT: (C)2021,JPOandINPIT

CHEMICAL PROCESS FOR PREPARING PYRIMIDINE DERIVATIVES AND INTERMEDIATES THEREOF

PROBLEM TO BE SOLVED: To provide a method for producing intermediates for preparing ceritinib. SOLUTION: There is provided a method for preparing (C2-1), comprising reacting (A) with (B) in a solvent in the presence of at least one catalyst, wherein P is a protecting group and T and X1 can be independently C1 and the like. SELECTED DRAWING: None COPYRIGHT: (C)2020,JPOandINPIT

The novel anti-tumor medicine synthetic method and a pharmaceutically acceptable salt thereof and solid preparation (by machine translation)

The invention discloses a method for synthesis of antineoplastic agent, the chemical name is 5 - chloro - N2 - (3 - amino-acetyl aminophenyl) - N4 - (2 - [...] phenyl) pyrimidine - 2, 4 - diamine. At the same time, its salt, crystalline form research, select and suitable for further development as a preparation of the maleate, tartrate and succinate and its corresponding crystalline form. The invention also provides a to the antineoplastic agent as the active ingredient of the solid preparation, wherein the supplemented with one or more solubilising. The invention solid preparation dissolution characteristic and excellent stability, with clinical application prospect. (by machine translation)