163359-11-3

Basic information

• Product Name: 3-Pyridineacetonitrile,alpha-methyl-(9CI)
• Synonyms: 3-Pyridineacetonitrile,alpha-methyl-(9CI)
• CAS NO: 163359-11-3
• Molecular Formula: C8H8N2
• Molecular Weight: 132.16252
• Product Categories: PYRIDINE
• Mol File: 163359-11-3.mol
• Article Data: 11

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3-Pyridineacetonitrile,alpha-methyl-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Pyridineacetonitrile,alpha-methyl-(9CI)(163359-11-3)
• EPA Substance Registry System: 3-Pyridineacetonitrile,alpha-methyl-(9CI)(163359-11-3)

Safety Data

• Hazardous Substances Data: 163359-11-3(Hazardous Substances Data)

Upstream product

• 143-33-9 sodium cyanide 
• 372-47-4 3-Fluoropyridine 
• 107-12-0 propiononitrile 
• 6443-85-2 3-pyridinylacetonitrile 
• 68-12-2 N,N-dimethyl-formamide 
• 1121-55-7 3-vinylpyridine 
• 23741-79-9 Isopropylmalonsauredinitril 
• 7677-24-9 trimethylsilyl cyanide 
• 4754-27-2 1-(3-Pyridyl)ethanol 
• 350-03-8 methyl-3-pyridylketone 
• 74-88-4 methyl iodide 
• 67-56-1 methanol 

Relevant articles and documents

2-(Pyridyl)-propionitriles and their aminomethylation

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Rhenium(I)-Catalyzed C-Methylation of Ketones, Indoles, and Arylacetonitriles Using Methanol

A ReCl(CO)5/MeC(CH2PPh2)3 (L2) system was developed for the C-methylation reactions utilizing methanol and base, following the borrowing hydrogen strategy. Diverse ketones, indoles, and arylacetonitriles underwent mono-and dimethylation selectively up to 99% yield. Remarkably, tandem multiple methylations were also achieved by employing this catalytic system.

Preparation method of alkyl nitrile compound

The invention discloses a preparation method of an alkyl nitrile compound. Specifically, the preparation method comprises the following step: in an organic solvent, in the presence of a protective gasand under the action of a catalyst, carrying out a reduction reaction as shown in the specification on olefin as shown in a formula I, a cyanation reagent and water, wherein the alkyl nitrile compound 1 is a compound II and/or a compound III. The preparation method provided by the invention is mild in condition, can realize hydrocyanation of olefin more safely and efficiently, and has good substrate universality and functional group compatibility.