1634-36-2

Basic information

• Product Name: 2'-HYDROXY-5'-ISOPROPYLACETOPHENONE
• Synonyms: 2'-HYDROXY-5'-ISOPROPYLACETOPHENONE;2-HYDROXY-5-ISOPROPYLPHENYLACETONE;1-(2-HYDROXY-5-ISOPROPYL-PHENYL)-ETHANONE;5-ISOPROPYL-2-HYDROXYACETOPHENONE;2-Acetyl-4-isopropylphenol, 1-[2-Hydroxy-5-(prop-2-yl)phenyl]ethan-1-one;Ethanone, 1-[2-hydroxy-5-(1-methylethyl)phenyl]-
• CAS NO: 1634-36-2
• Molecular Formula: C₁₁H₁₄O₂
• Molecular Weight: 178.23
• Product Categories: Aromatic Acetophenones & Derivatives (substituted)
• Mol File: 1634-36-2.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 258℃
• Flash Point: 107℃
• Appearance: /
• Density: 1.051
• PKA: 10.44±0.18(Predicted)
• CAS DataBase Reference: 2'-HYDROXY-5'-ISOPROPYLACETOPHENONE(CAS DataBase Reference)
• NIST Chemistry Reference: 2'-HYDROXY-5'-ISOPROPYLACETOPHENONE(1634-36-2)
• EPA Substance Registry System: 2'-HYDROXY-5'-ISOPROPYLACETOPHENONE(1634-36-2)

Safety Data

• Hazardous Substances Data: 1634-36-2(Hazardous Substances Data)

Usage

Preparation

Preparation by reaction of acetyl chloride on 4-isopropylanisole with aluminium chloride in carbon disulfide at r.t. (48%).

Upstream product

• 4132-48-3 1-methoxy-4-(1-methylethyl)benzene 
• 75-36-5 acetyl chloride 
• 2664-32-6 4-isopropylphenyl acetate 
• 127-19-5 N,N-dimethyl acetamide 
• 58456-88-5 2-iodo-4-(1-methylethyl)phenol 
• 30989-71-0 2-diethoxymethyl-1,1-diethoxy-3-methylbutane 
• 63446-76-4 1-methyl-1,3-bis(trimethylsilyloxy)buta-1,3-diene 
• 99-89-8 4-Isopropylphenol 

Downstream Products

• 132020-62-3 (E)-3-(4-Benzyloxy-phenyl)-1-(2-hydroxy-5-isopropyl-phenyl)-propenone 
• 1634-65-7 2-Aethyl-4-isopropyl-phenol 
• 49619-58-1 3-formyl-6-isopropylchromone 
• 644964-08-9 1-(2-hydroxy-3-iodo-5-isopropyl-phenyl)-ethanone 
• 644964-10-3 6-isopropyl-4-methyl-8-phenyl-chromen-2-one 
• 644964-16-9 2-((Z)-3-Hydroxy-1-methyl-propenyl)-4-isopropyl-6-pentafluoroethyl-phenol 
• 644964-20-5 (Z)-3-(5-Isopropyl-3-pentafluoroethyl-2-propoxy-phenyl)-but-2-enal 
• 644964-18-1 (Z)-3-(5-Isopropyl-3-pentafluoroethyl-2-propoxy-phenyl)-but-2-en-1-ol 
• 644964-22-7 (2E,4E,6Z)-7-(5-Isopropyl-3-pentafluoroethyl-2-propoxy-phenyl)-3-methyl-octa-2,4,6-trienoic acid ethyl ester 
• 132020-74-7 2-(4-Benzyloxy-phenyl)-6-isopropyl-3-methoxy-chromen-4-one 
• 1634-67-9 (+/-)-3-<2-Aethyl-4-isopropyl-phenoxy>-butan-2-on 
• 288399-58-6 C₁₂H₁₂O₂ 

Relevant articles and documents

2, 4-diaminopyrimidine compound containing phenol fragment, preparation method, pharmaceutical compositions and use thereof

The invention discloses a 2, 4-diaminopyrimidine compound containing phenol fragment with a general formula I shown in the specification, pharmaceutically acceptable salts or pharmaceutically acceptable solvates, a preparation method thereof, pharmaceutical compositions containing the compounds, and use of the compounds in preparation of drugs for preventing or treating anaplastic lymphoma kinaserelated abnormal cell proliferation, morphological changes, hyperkinesia and other associated diseases in organisms, and angiogenesis or cancerometastasis associated diseases, especially use in drugsfor treating or preventing tumor growth and metastasis.

Design and syntheses of novel N′-((4-oxo-4H-chromen-3-yl)methylene) benzohydrazide as inhibitors of cyanobacterial fructose-1,6-/sedoheptulose-1,7- bisphosphatase

Cyanobacterial fructose-1,6-/sedoheptulose-1,7-bisphoshatase (Cy-FBP/SBPase) is an important target enzyme for finding inhibitors to solve harmful algal bloom (HAB). In this study, as potential inhibitors of Cy-FBP/SBPase, a series of novel chromone-connecting benzohydrazone compounds (Novel N′-((4-oxo-4H-chromen-3-yl)methylene)benzohydrazide) were designed and synthesized. Their inhibitory activities against Cy-FBP/SBPase were further examined in vitro. Some of these compounds, such as f6-f8, f11, f12 and f16, exhibit higher inhibitory activities (IC50 = 11.2-16.1 μM), especially, the compound f7 was identified as the most potent inhibitor with IC50 value of 11.2 μM. The probable binding-mode of compound f7 was further analyzed carefully by molecular docking methods. These results indicate that compound f7 could be used as a lead compound for further optimization and might have potential to be developed as a new algicide.

Regioselective synthesis of 5-alkylsalicylates, 5-alkyl-2-hydroxy- acetophenones, and 5-alkyl-2-hydroxy-benzophenones by [3 + 3] cyclization of 1,3-bis(silyl enol ethers) with 2-alkyl-1,1,3,3-tetraethoxypropanes

(Chemical Equation Presented) A variety of 5-alkylsalicylates, 5-alkyl-2-hydroxy-acetophenones, and 5-alkyl-2-hydroxy-benzophenones was regioselectively prepared by TiCl4 mediated formal [3 + 3] cyclization of 1,3-bis(silyl enol ethers) with 2-alkyl-1,1,3,3- tetraethoxypropanes.