16344-79-9

Basic information

• Product Name: Pyridine, 2-[(4-methoxyphenyl)ethynyl]-
• CAS NO: 16344-79-9
• Molecular Formula: C14H11NO
• Molecular Weight: 209.247
• Mol File: 16344-79-9.mol
• Article Data: 21

Chemical Properties

• CAS DataBase Reference: Pyridine, 2-[(4-methoxyphenyl)ethynyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Pyridine, 2-[(4-methoxyphenyl)ethynyl]-(16344-79-9)
• EPA Substance Registry System: Pyridine, 2-[(4-methoxyphenyl)ethynyl]-(16344-79-9)

Safety Data

• Hazardous Substances Data: 16344-79-9(Hazardous Substances Data)

Upstream product

• 1945-84-2 2-ethynylpyridine 
• 696-62-8 para-iodoanisole 
• 18438-38-5 2-methylsulfanyl-pyridine 
• 768-60-5 4-methoxyphenylacetylen 
• 109-09-1 2-chloropyridine 
• 5029-67-4 2-iodopyridine 
• 104-92-7 1-bromo-4-methoxy-benzene 
• 33397-21-6 tris(4-methoxyphenyl)bismuth 
• 182815-94-7 2-(2,2-dibromovinyl)-pyridine 
• 86521-05-3 2-(trimethylsilylethynyl)pyridine 
• 3989-14-8 (4-methoxyphenylethynyl)trimethylsilane 
• 109-04-6 2-bromo-pyridine 

Downstream Products

• 710946-95-5 2-[5-(4-methoxy-phenyl)-2H-[1,2,3]triazol-4-yl]-pyridine 
• 1006057-77-7 2-(4-methoxyphenyl)-3-pyridin-2-yl-1H-indole-6-carboxylic acid methyl ester 
• 1006057-69-7 3-(4-methoxyphenyl)-2-pyridin-2-yl-1H-indole-6-carboxylic acid methyl ester 
• 1569271-19-7 C₂₄H₂₆Cl₂IrNO 
• 906753-69-3 1-(but-3-enyl)-2-(4-methoxy-phenyl-ethynyl)-pyridinium triflate 
• 40061-36-7 1-(4-methoxyphenyl)-2-(pyridine-2-yl)ethane-1,2-dione 
• 710947-00-5 4-[4-(4-methoxy-phenyl)-5-pyridin-2-yl-[1,2,3]triazol-2-ylmethyl]-benzonitrile 
• 710947-11-8 4-[4-(4-methoxy-phenyl)-5-pyridin-2-yl-[1,2,3]triazol-2-yl]-benzonitrile 

Relevant articles and documents

Sonogashira Cross-Coupling of Aryltrimethylammonium Salts

A protocol for C(sp)-C(sp2) bond formation via the Sonogashira coupling reaction involving C-N bond cleavage with aryltrimethylammonium triflate as an electrophilic coupling partner is described in this work. The reactions proceeded well under mild conditions with a stoichiometric ratio of alkyl, aryl, or heteroaryl acetylenes and provided yields of up to 93%. Numerous useful functional groups were tolerated under the reaction conditions. Direct amine alkynylation can be achieved through a one-pot process without the isolation of ammonium salt. The protocol can be performed on a gram scale. Density functional theory calculations were performed to investigate the reaction mechanism that involved oxidative addition, alkyne coordination, deprotonation, and reductive elimination, which yielded the cross-coupling product.

Method for synthesizing phenylethynyl pyridine derivative

The invention discloses a method for synthesizing a phenylethynyl pyridine derivative. The method takes palladium acetate as a catalyst, 4,5-bisdiphenylphosphine-9,9-dimethoxyxanthene as a ligand andmethanol as a solvent; 2-iodopyridine and a phenylacetylene type compound are coupled to prepare the phenylethynyl pyridine derivative. The method disclosed by the invention has the advantages of simplicity in operation, efficient reaction, moderate conditions and good substrate applicability and can be widely used for preparing the phenylethynyl pyridine derivative.

An N-heterocyclic carbene based MOF catalyst for Sonogashira cross-coupling reaction

The post-synthetic modification of azolium containing MOFs generated a new heterogeneous N-heterocyclic carbene catalyst (1-Pd), which is very active for Sonogashira cross coupling reaction.