163496-06-8

Basic information

• Product Name: Uridine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2-thio-
• CAS NO: 163496-06-8
• Molecular Formula: C30H30N2O7S
• Molecular Weight: 562.643
• Mol File: 163496-06-8.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: Uridine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2-thio-(CAS DataBase Reference)
• NIST Chemistry Reference: Uridine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2-thio-(163496-06-8)
• EPA Substance Registry System: Uridine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2-thio-(163496-06-8)

Safety Data

• Hazardous Substances Data: 163496-06-8(Hazardous Substances Data)

Usage

General Description

Uridine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2-thio- is a chemical compound with a unique structure that includes a uridine base linked to a 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2-thio group. Uridine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2-thio- belongs to the class of uridine derivatives and has potential pharmacological applications, particularly in the field of neuroscience and neuropharmacology. The presence of the 2-thio group may confer specific biological activity or binding properties, making it of interest for research and development in the pharmaceutical industry. Further studies and research are needed to elucidate the full potential and applications of this compound in various fields related to human health and medicine.

Upstream product

• 40615-36-9 4,4'-dimethoxytrityl chloride 
• 20235-78-3 2-thiouridine 

Downstream Products

• 1384570-83-5 5'-O-dimetoxytrityl-2-selenouridine 
• 1627601-87-9 5'-O-dimethoxytrityl-S-geranyl-2-thiouridine 
• 1384570-81-3 C₃₁H₃₂N₂O₇S 
• 1262964-71-5 C₄₈H₆₄N₅O₈PSeSi 
• 1384570-93-7 C₃₉H₄₇N₃O₇SeSi 
• 1384570-90-4 C₃₉H₄₇N₃O₇SeSi 
• 1384570-85-7 5′-O-(4,4′-dimetoxytrityl)-2′-O-tert-butyldimethylsilyl-2-selenouridine 
• 1384570-88-0 C₃₆H₄₄N₂O₇SeSi 

Relevant articles and documents

S-Geranyl-2-thiouridine wobble nucleosides of bacterial tRNAs; Chemical and enzymatic synthesis of S-geranylated-RNAs and their physicochemical characterization

Recently, highly lipophilic S-geranylated derivatives of 5-methylaminomethyl-2-thiouridine (mnm5geS2U) and 5-carboxymethylaminomethyl-2-thiouridine (cmnm5geS2U) were found at the first (wobble) anticodon position in bacterial tRNAs specific for Lys, Glu and Gln. The function and cellular biogenesis of these unique tRNAs remain poorly understood. Here, we present one direct and two post-synthetic chemical routes for preparing model geS2U-RNAs. Our experimental data demonstrate that geS2U-RNAs are more lipophilic than their parent S2U-RNAs as well as non-modified U-RNAs. Thermodynamic studies revealed that the S-geranyl-2-thiouridine-containing RNA has higher affinity toward complementary RNA strand with G opposite the modified unit than with A. Recombinant tRNA selenouridine synthase (SelU) exhibits sulfur-specific geranylation activity toward model S2U-RNA, which is composed of the anticodon-stem-loop (ASL) from the human tRNALys3 sequence. In addition, the presence of magnesium ions is required to achieve appreciable geranylation efficiencies.