163705-72-4

Basic information

• Product Name: 1-(3-cyclopentyloxy-4-methoxyphenyl)-1-phenylmethanol
• Synonyms: 1-(3-cyclopentyloxy-4-methoxyphenyl)-1-phenylmethanol
• CAS NO: 163705-72-4
• Molecular Weight: 298.382
• Mol File: 163705-72-4.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 1-(3-cyclopentyloxy-4-methoxyphenyl)-1-phenylmethanol(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(3-cyclopentyloxy-4-methoxyphenyl)-1-phenylmethanol(163705-72-4)
• EPA Substance Registry System: 1-(3-cyclopentyloxy-4-methoxyphenyl)-1-phenylmethanol(163705-72-4)

Safety Data

• Hazardous Substances Data: 163705-72-4(Hazardous Substances Data)

Upstream product

• 100-58-3 phenylmagnesium bromide 
• 67387-76-2 3-cyclopentyloxy-4-methoxybenzylaldehyde 
• 137-43-9 Cyclopentyl bromide 
• 621-59-0 isovanillin 
• 108-86-1 bromobenzene 
• 7429-90-5 aluminium 

Downstream Products

• 162543-72-8 [3-(cyclopentyloxy)-4-methoxyphenyl]phenylmethanone 
• 162543-81-9 (E)-2-[3-(cyclopentyloxy)-4-methoxyphenyl]-2-phenyl-1-(4-pyridyl)ethene 
• 162543-82-0 4-[(Z)-2-(3-Cyclopentyloxy-4-methoxy-phenyl)-2-phenyl-vinyl]-pyridine 
• 190204-35-4 4-[(E)-2-(3-Cyclopentyloxy-4-methoxy-phenyl)-2-phenyl-vinyl]-pyridine 
• 468736-83-6 2-Cyclopentyloxy-4-((E)-1,2-diphenyl-vinyl)-1-methoxy-benzene 
• 162544-01-6 2-Cyclopentyloxy-1-methoxy-4-(1-phenyl-vinyl)-benzene 
• 190204-71-8 4-[2-(3-cyclopentyloxy-4-methoxyphenyl)-2-(phenyl)ethyl]pyridine 

Relevant articles and documents

Improvement of therapeutic index of phosphodiesterase type IV inhibitors as anti-asthmatics

A new series of catechol hydrazines was synthesized and their structure-activity relationship (SAR) was analyzed for developing an effective phosphodiesterase 4 (PDE4) inhibitor as an anti-asthmatic drug candidate. Among the (E)-Analogues tested using in

Phenylpyridyl compounds for inhibiting phosphodiesterase IV and methods of using same

PCT No. PCT/US96/00519 Sec. 371 Date Nov. 13, 1997 Sec. 102(e) Date Nov. 13, 1997 PCT Filed Jan. 11, 1996 PCT Pub. No. WO96/21435 PCT Pub. Date Jul. 18, 1996Novel compounds which are effective PDE IV inhibitors are disclosed. The compounds possess improve

Asymmetric synthesis of CDP840 by Jacobsen epoxidation. An unusual syn selective reduction of an epoxide

An asymmetric synthesis of the PDE IV inhibitor, CDP840 (3) is reported. The absolute stereochemistry was controlled by a Jacobsen epoxidation of the Z triaryl olefin 8 (89% ee) or the E triaryl olefin 9 (48% ee). The disparate results in stereocontrol were interpreted in terms of the 'skewed side-on approach model' proposed by Jacobsen. LiBH4 · BH3 reduction of the epoxides was found to proceed with retention of configuration.