163706-58-9 Usage
Description
(2R,3S,4R,5R)-2-(hydroxyMethyl)-5-(6-((2-(Methylthio)ethyl)aMino)-2-((3,3,3-trifluoropropyl)thio)-9H-purin-9-yl)tetrahydrofuran-3,4-diol is a complex organic compound with a unique molecular structure. It is characterized by its chiral centers at the 2nd, 3rd, 4th, and 5th positions, which are all in the R or S configuration. (2R,3S,4R,5R)-2-(hydroxyMethyl)-5-(6-((2-(Methylthio)ethyl)aMino)-2-((3,3,3-trifluoropropyl)thio)-9H-purin-9-yl)tetrahydrofuran-3,4-diol features a hydroxymethyl group at the 2nd position, a tetrahydrofuran ring, and a 9H-purin-9-yl group at the 5th position. Additionally, it has a 6-((2-(methylthio)ethyl)amino)-2-((3,3,3-trifluoropropyl)thio) substitution pattern, which contributes to its potential biological activity.
Uses
Used in Pharmaceutical Industry:
(2R,3S,4R,5R)-2-(hydroxyMethyl)-5-(6-((2-(Methylthio)ethyl)aMino)-2-((3,3,3-trifluoropropyl)thio)-9H-purin-9-yl)tetrahydrofuran-3,4-diol is used as a key intermediate in the development of platelet P2T receptor antagonists. These antagonists have potential applications in antithrombotic therapy, which aims to prevent blood clot formation and reduce the risk of thrombotic disorders such as stroke, heart attack, and deep vein thrombosis. The unique structure and chiral configuration of this compound make it a promising candidate for the design and synthesis of novel therapeutic agents with improved efficacy and selectivity in treating thrombotic-related conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 163706-58-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,6,3,7,0 and 6 respectively; the second part has 2 digits, 5 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 163706-58:
(8*1)+(7*6)+(6*3)+(5*7)+(4*0)+(3*6)+(2*5)+(1*8)=139
139 % 10 = 9
So 163706-58-9 is a valid CAS Registry Number.
163706-58-9Relevant articles and documents
Industrialized preparation method of Cangrelor intermediate
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Paragraph 0029; 0030, (2019/02/25)
The invention discloses an industrialized preparation method of a Cangrelor intermediate (shown as a formula I). After 6-chloro-2-((3,3,3-trifluoromethylpropyl)thio)-7H-purine react with 1,2,3,5-tetraacetyl-beta-D-ribofuranose under the action of Lewis acid, a product reacts with 2-(thiomethyl)ethylamine hydrochloride under an alkaline condition; a product is hydrolyzed under the alkaline condition to generate the Cangrelor intermediate. The method is low in technological cost, safe and reliable to operate and suitable for large-scale industrial production. The formula I is shown in the description.
Development of a Novel and Scalable Process for the Synthesis of a Key Cangrelor Intermediate
Guvvala, Vinodh,Subramanian, Venkatesan Chidambaram,Anireddy, Jayashree
, p. 530 - 536 (2019/11/19)
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Preparation method for 6-N-[2-(methylthio)ethyl]-2-[(3,3,3-trifluoropropyl)thio]adenosine
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, (2018/05/16)
The invention discloses a preparation method for 6-N-[2-(methylthio)ethyl]-2-[(3,3,3-trifluoropropyl)thio]adenosine. The preparation method comprises the following steps: subjecting a compound as shown in a formula (8) to glycosylation so as to obtain a c
