16375-92-1

Basic information

• Product Name: N-[4-(1-Hydroxyethyl)phenyl]acetamide
• Synonyms: 4'-(1-Hydroxyethyl)acetanilide;N-[4-(1-Hydroxyethyl)phenyl]acetamide;4-(+/-)-±-hydroxyethylphenylacetamide
• CAS NO: 16375-92-1
• Molecular Formula: C₁₀H₁₃NO₂
• Molecular Weight: 179.22
• Mol File: 16375-92-1.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• CAS DataBase Reference: N-[4-(1-Hydroxyethyl)phenyl]acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-[4-(1-Hydroxyethyl)phenyl]acetamide(16375-92-1)
• EPA Substance Registry System: N-[4-(1-Hydroxyethyl)phenyl]acetamide(16375-92-1)

Safety Data

• Hazardous Substances Data: 16375-92-1(Hazardous Substances Data)

Upstream product

• 2719-21-3 4-(N-acetylamino)acetophenone 
• 93453-80-6 1-(4-aminophenyl)ethanol 
• 108-24-7 acetic anhydride 
• 3663-34-1 N-(4-ethylphenyl)acetamide 
• 100-19-6 (4-nitrophenyl)ethanone 

Downstream Products

• 351-83-7 4'-fluoroacetanilide 
• 2719-21-3 4-(N-acetylamino)acetophenone 
• 120342-68-9 methyl N-(4-(1-azidoethyl)phenyl)acetamide 
• 1260236-30-3 N-(1-(4-acetamidophenyl)vinyl)acetamide 
• 122-80-5 N-acetyl-p-phenylenediamine 

Relevant articles and documents

Estimation of the rates of available fraction for some 4-substituted acetophenone derivatives in the rat: Reversible drug-metabolite pharmacokinetics

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Ni2P Nanoalloy as an Air-Stable and Versatile Hydrogenation Catalyst in Water: P-Alloying Strategy for Designing Smart Catalysts

Non-noble metal-based hydrogenation catalysts have limited practical applications because they exhibit low activity, require harsh reaction conditions, and are unstable in air. To overcome these limitations, herein we propose the alloying of non-noble metal nanoparticles with phosphorus as a promising strategy for developing smart catalysts that exhibit both excellent activity and air stability. We synthesized a novel nickel phosphide nanoalloy (nano-Ni2P) with coordinatively unsaturated Ni active sites. Unlike conventional air-unstable non-noble metal catalysts, nano-Ni2P retained its metallic nature in air, and exhibited a high activity for the hydrogenation of various substrates with polar functional groups, such as aldehydes, ketones, nitriles, and nitroarenes to the desired products in excellent yields in water. Furthermore, the used nano-Ni2P catalyst was easy to handle in air and could be reused without pretreatment, providing a simple and clean catalyst system for general hydrogenation reactions.

A unified photoredox-catalysis strategy for C(sp3)-H hydroxylation and amidation using hypervalent iodine

We report a unified photoredox-catalysis strategy for both hydroxylation and amidation of tertiary and benzylic C-H bonds. Use of hydroxyl perfluorobenziodoxole (PFBl-OH) oxidant is critical for efficient tertiary C-H functionalization, likely due to the enhanced electrophilicity of the benziodoxole radical. Benzylic methylene C-H bonds can be hydroxylated or amidated using unmodified hydroxyl benziodoxole oxidant Bl-OH under similar conditions. An ionic mechanism involving nucleophilic trapping of a carbocation intermediate by H2O or CH3CN cosolvent is presented.