163798-87-6

Basic information

• Product Name: tert-butyl 2-(chloromethyl)-1H-benzimidazole-1-carboxylate
• Synonyms: tert-butyl 2-(chloromethyl)-1H-benzimidazole-1-carboxylate;1-(tert-Butoxycarbonyl)-2-(chloromethyl)-benzimidazole;tert-butyl 2-(chloroMethyl)-1H-benzo[d]iMidazole-1-carboxylate;1H-BenziMidazole-1-carboxylic acid, 2-(chloroMethyl)-, 1,1-diMethylethyl ester
• CAS NO: 163798-87-6
• Molecular Formula: C₁₃H₁₅ClN₂O₂
• Molecular Weight: 266.7234
• Mol File: 163798-87-6.mol
• Article Data: 12

Chemical Properties

• Boiling Point: 377.6±44.0 °C(Predicted)
• Appearance: /
• Density: 1.23±0.1 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 2.01±0.10(Predicted)
• CAS DataBase Reference: tert-butyl 2-(chloromethyl)-1H-benzimidazole-1-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl 2-(chloromethyl)-1H-benzimidazole-1-carboxylate(163798-87-6)
• EPA Substance Registry System: tert-butyl 2-(chloromethyl)-1H-benzimidazole-1-carboxylate(163798-87-6)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 163798-87-6(Hazardous Substances Data)

Usage

General Description

Tert-butyl 2-(chloromethyl)-1H-benzimidazole-1-carboxylate is a chemical compound that is a derivative of benzimidazole. It is a carboxylate ester with a tert-butyl group, a chloromethyl group, and a benzimidazole ring. tert-butyl 2-(chloromethyl)-1H-benzimidazole-1-carboxylate is commonly used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. It has also been studied for its potential applications in the field of medicinal chemistry, particularly as a potential anti-cancer agent. Tert-butyl 2-(chloromethyl)-1H-benzimidazole-1-carboxylate is a versatile and potentially valuable compound in the field of organic chemistry.

Upstream product

• 4857-04-9 2-chloromethyl-1H-benzimidazole 
• 24424-99-5 di-tert-butyl dicarbonate 
• 95-54-5 1,2-diamino-benzene 

Downstream Products

• 305357-42-0 ethyl 4-O-allyl-3,4-dihydroxybenzoate 
• 865202-97-7 C₃₆H₅₁N₅O₆ 

Relevant articles and documents

TRANSGLUTAMINASE 2 (TG2) INHIBITORS

Described herein are compounds and pharmaceutical compositions containing such compounds which inhibit transglutaminase 2 (TG2). Also described herein are methods for using such TG2 inhibitors, alone or in combination with other compounds, for treating diseases or conditions that would benefit from TG2 inhibition.

Multi-substituted amine compound and its preparation and use (by machine translation)

The invention belongs to the field of medical technology, in particular, the present invention provides the following formula I shown multi-substituted amine compound or its isomer or its pharmaceutically acceptable salt, ester, prodrug or hydrate, its pharmaceutical composition, preparation method thereof and its use in the preparation of medicine for treating aids in use. The compound or pharmaceutical composition containing the compound can be used as an inhibitor for inhibiting HIV integrase with LEDGF/p75 between protein - protein interaction and HIV integrase dimerization, then can be used for the treatment of aids. . (by machine translation)

PIPERIDINONES USEFUL IN THE TREATMENT OF INFLAMMATION

There is provided compounds of formula (I): wherein R1, R2, R3, R4, R5, R6, R7, m and n have meanings given in the description, and pharmaceutically acceptable derivatives thereof, which compounds are useful in the treatment of diseases and conditions associated with inflammation.