163837-32-9

Basic information

• Product Name: (S)-p-Chlorophenyl-phenylMethanaMine
• Synonyms: (S)-p-Chlorophenyl-phenylMethanaMine;(S)-(4-chlorophenyl)(phenyl)MethanaMine;(S)-^a-(4-Chlorophenyl)benzylaMine, 98%;(S)-alpha-(4-Chlorophenyl)benzylamine
• CAS NO: 163837-32-9
• Molecular Formula: C₁₃H₁₂ClN
• Molecular Weight: 217.69408
• Mol File: 163837-32-9.mol
• Article Data: 13

Chemical Properties

• Boiling Point: 336.8±27.0 °C(Predicted)
• Appearance: /Solid
• Density: 1.175±0.06 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 8.08±0.10(Predicted)
• CAS DataBase Reference: (S)-p-Chlorophenyl-phenylMethanaMine(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-p-Chlorophenyl-phenylMethanaMine(163837-32-9)
• EPA Substance Registry System: (S)-p-Chlorophenyl-phenylMethanaMine(163837-32-9)

Safety Data

• Hazardous Substances Data: 163837-32-9(Hazardous Substances Data)

Usage

General Description

(S)-p-Chlorophenyl-phenylMethanaMine, also known as (S)-PCP, is a chemical compound that belongs to the class of phenylmorpholines and acts as a psychoactive drug. It is a potent hallucinogen and dissociative anesthetic with effects similar to those of phencyclidine (PCP). The chemical is known to interact with the brain's neurotransmitter systems, particularly the glutamatergic system, leading to its psychoactive effects. (S)-PCP is commonly used as a recreational drug, and its use can result in unpredictable and dangerous effects, including hallucinations, delusions, and disorientation.

Upstream product

• 260997-46-4 (S)-(+)-N-[(4-chlorophenyl)phenylmethyl]-4-nitrobenzenesulfonamide 
• 336105-23-8 (R)-(-)-N-[(1E)-(4-chlorophenyl)methylene]-2-methyl-2-propanesulfinamide 
• 439695-63-3 (R_S,S)-(1-(4-chlorophenyl)-1-phenylmethyl)-2-methylpropanesulfinamide 
• 796966-17-1 (S)-N-((4-chlorophenyl)(phenyl)methyl)-4-methylbenzenesulfonamide 
• 16635-23-7 phenyltriisopropoxytitanium(IV) 
• 3262-89-3 triphenylboroxine 
• 104-88-1 4-chlorobenzaldehyde 
• 260997-38-4 N-(4-chloro-benz-(E)-ylidene)-4-nitro-benzenesulfonamide 
• 357417-22-2 N-(4-chlorobenzylidene)-4-methylbenzenesulfonamide 
• 100-52-7 benzaldehyde 
• 186249-76-3 (R,E)-2-methyl-N-(phenylmethylene)-2-propanesulfinamide 
• 934-56-5 trimethyl(phenyl)stannane 
• 474654-19-8 (S)-(-)-N-[(4-chlorophenyl)(phenyl)methyl]formamide 
• 1309582-68-0 N,N'-sulfonyl bis-[(4-chlorophenyl)(phenyl)methanamine] 

Downstream Products

• 292066-77-4 [(S)-(4-Chloro-phenyl)-phenyl-methyl]-(2,2-dimethoxy-ethyl)-amine 
• 163837-58-9 1-[(S)-(4-Chloro-phenyl)-phenyl-methyl]-4-(toluene-4-sulfonyl)-piperazine 
• 130018-87-0 (+)-Cetirizine dihydrochloride 
• 439858-21-6 1-[(S)-(4-chlorophenyl)(phenyl)methyl]piperazine 
• 246870-46-2 (S)-(-)-cetirizine ethyl ester 
• 292066-78-5 N-[(4-chloro-phenyl)-phenyl-methyl]-N-(2,2-dimethoxy-ethyl)-formamide 
• 1246755-20-3 (S)-(+)-N-[(4-chlorophenyl)(phenyl)methyl]pivalamide 
• 1198162-46-7 (-)-1-[(4-chloro-phenyl)-phenyl-methyl]-4-(4-methoxy-benzyl)piperazine 
• 134-85-0 4-chlorobenzophenone 
• 41839-60-5 p-chlorobenzophenone imine 

Relevant articles and documents

C2-symmetric bicyclo[2.2.2]octadienes as chiral ligands: Their high performance in rhodium-catalyzed asymmetric arylation of N-tosylarylimines

Asymmetric synthesis of diarylmethylamines with high enantioselectivity (95-99% ee) was realized by use of a new C2-symmetric diene ligand, (1R,4R)-2,5-diphenylbicyclo[2.2.2]octa-2,5-diene (Ph-bod*), for the rhodium-catalyzed asymmetric arylati

Simultaneous engineering of an enzyme's entrance tunnel and active site: The case of monoamine oxidase MAO-N

A new directed evolution approach is presented to enhance the activity of an enzyme and to manipulate stereoselectivity by focusing iterative saturation mutagenesis (ISM) simultaneously on residues lining the entrance tunnel and the binding pocket. This combined mutagenesis strategy was applied successfully to the monoamine oxidase from Aspergillus Niger (MAO-N) in the reaction of sterically demanding substrates which are of interest in the synthesis of chiral pharmaceuticals based on the benzo-piperidine scaffold. Reversal of enantioselectivity of Turner-type deracemization was achieved in the synthesis of (S)-1,2,3,4-tetrahydro-1-methyl-isoquinoline, (S)-1,2,3,4-tetrahydro-1-ethylisoquinoline and (S)-1,2,3,4-tetrahydro-1-isopropylisoquinoline. Extensive molecular dynamics simulations indicate that the altered catalytic profile is due to increased hydrophobicity of the entrance tunnel acting in concert with the altered shape of the binding pocket.

Bis-sulfamyl imines: Potent substrates for asymmetric additions of arylboroxines under rhodium catalysis

Bis-sulfamyl imines are shown to be potentially ideal substrates for rhodium-catalysed asymmetric additions of arylboron nucleophiles as they show: (i) near perfect enantioselectivities (11 examples, 98-99+% ee), (ii) good to excellent diastereoselectivities (10-32:1 rac:meso), and (iii) high functional group tolerance in removal of the low molecular weight protecting group via mild heating in aqueous pyridine.