16387-72-7Relevant articles and documents
A convenient synthesis of 1,4,5-trisubstituted 1,2,3-triazoles via 1,3-dipolar cycloaddition/coupling of alkynes, phenylboronic acids, and sodium azide catalyzed by Cu(I)/Cu(II)
Yang, Dong,Fu, Na,Liu, Zenglu,Li, Ying,Chen, Baohua
, p. 278 - 282 (2007)
A series of 1,4,5-trisubstituted 1,2,3-triazoles was prepared simply and conveniently via 1,3-dipolar cycloaddition/coupling reaction of terminal alkynes, phenylboronic acids and sodium azide in 1,4-dioxane-water using CuI/CuSO4 as catalyst. Georg Thieme Verlag Stuttgart.
Copper(II)/Palladium(II) catalysed highly selective cross-coupling of terminal alkynes in supercritical carbon dioxide
Wang, Yunlong,Suo, Quanling,Han, Limin,Guo, Linlin,Wang, Yaqi,Li, Fawang
, p. 1918 - 1925 (2018/03/12)
An efficient protocol for the synthesis of unsymmetrical 1,3-diynes was developed using supercritical carbon dioxide (ScCO2) as the solvent. The direct coupling of two different terminal alkynes is catalysed by a bimetallic catalyst, CuCl2·2H2O/Pd(NH3)4Cl2·H2O, in the presence of the base tetramethylethylenediamine (TMEDA) and O2. In pure ScCO2, our bimetallic catalytic system maintains high activity over a wide substrate scope to provide unsymmetrical 1,3-diynes in good to excellent yields. In the proposed reaction mechanism, the synergistic cooperation between copper(II) and palladium(II) centres is responsible for the superior selectivity of the cross-coupling.
Copper-catalyzed cross-coupling of alkyl and aryl grignard reagents with alkynyl halides
Cahiez, Gerard,Gager, Olivier,Buendia, Julien
supporting information; experimental part, p. 1278 - 1281 (2010/05/18)
(Chemical Equation Presented) Good old copperl A new general procedure to couple aliphatic and aromatic Grignard reagents with alkynyl halides under copper catalysis is described (see scheme; NMP=N-methylpyrrolidinone). The reaction is chemoselective and allows preparation of a vast array of simple and functionalized internal alkynes in high yields.
