163882-50-6

Basic information

• Product Name: (2R,3S,5R)-2-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(6-methylsulfanyl-purin-9-yl)-tetrahydro-furan-3-ol
• CAS NO: 163882-50-6
• Molecular Weight: 584.696
• Mol File: 163882-50-6.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (2R,3S,5R)-2-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(6-methylsulfanyl-purin-9-yl)-tetrahydro-furan-3-ol(CAS DataBase Reference)
• NIST Chemistry Reference: (2R,3S,5R)-2-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(6-methylsulfanyl-purin-9-yl)-tetrahydro-furan-3-ol(163882-50-6)
• EPA Substance Registry System: (2R,3S,5R)-2-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(6-methylsulfanyl-purin-9-yl)-tetrahydro-furan-3-ol(163882-50-6)

Safety Data

• Hazardous Substances Data: 163882-50-6(Hazardous Substances Data)

Upstream product

• 342-69-8 6-methylmercaptopurine riboside 
• 2239-64-7 6-mercaptopurine-2’-deoxyribose 
• 23526-11-6 S-methylthiodeoxyinosine 
• 40615-36-9 4,4'-dimethoxytrityl chloride 

Relevant articles and documents

Post-synthetic introduction of labile functionalities onto purine residues via 6-methylthiopurines in oligodeoxyribonucleotides

Two methods are described for the preparation of oligodeoxynucleotides containing 6-methylthiopurine residues. 6-Methylthiopurine phosphoramidite (6) has been prepared and incorporated into oligomers. Methylation with methyl iodide of 6-thiopurine (or 6-thioguanine) in oligomers also exclusively produces oligomers containing 6-methylthiopurine (or 6-methylthioguanine). The methylthio group at defined purine residues in the deprotected oligomers can be oxidized selectively and converted at the final step into various functional groups including radioactive 35S-thio group, a useful tag for cross-linking studies.

Preparation of oligodeoxynucleotides containing 6-methylthiopurine residues by chemical synthesis or specific methylation

Two methods (chemical synthesis and specific methylation) are described for the preparation of oligodeoxynucleotides containing 6-methylthiopurine residues. 6-Methylthiopurine phosphoramidite (6) is prepared and incorporated into oligomers. Methylation with methyl iodide of 6-thiopurine (or 6-thioguanine) in oligonucleotides also leads to exclusive production of 6-methylthiopurine (or 6-methylthioguanine) oligomers.