1639441-20-5

Basic information

• Product Name: C₁₇H₁₆N₂O
• Synonyms: C₁₇H₁₆N₂O
• CAS NO: 1639441-20-5
• Molecular Weight: 264.327
• Mol File: 1639441-20-5.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: C₁₇H₁₆N₂O(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₇H₁₆N₂O(1639441-20-5)
• EPA Substance Registry System: C₁₇H₁₆N₂O(1639441-20-5)

Safety Data

• Hazardous Substances Data: 1639441-20-5(Hazardous Substances Data)

Upstream product

• 40061-45-8 1-phenyl-2-(pyrazin-2-yl)ethanone 
• 1639441-12-5 C₁₉H₂₀N₂O₄ 

Relevant articles and documents

Iridium-Catalyzed Intramolecular Asymmetric Allylic Dearomatization Reaction of Pyridines, Pyrazines, Quinolines, and Isoquinolines

The first Ir-catalyzed intramolecular asymmetric allylic dearomatization reaction of pyridines, pyrazines, quinolines, and isoquinolines has been developed. Enabled by in situ formed chiral Ir-catalyst, the dearomatized products were isolated in high levels of yield (up to 99% yield) and enantioselectivity (up to 99% ee). It is worth noting that the Me-THQphos ligand is much more efficient than other tested ligands for the dearomatization of pyrazines and certain quinolines. Mechanistic studies of the dearomatization reaction were carried out, and the results suggest the feasibility of an alternative process which features the formation of a quinolinium as the key intermediate. The mechanistic findings render this reaction a yet unknown type in the chemistry of Reissert-type reactions. In addition, the utility of this method was showcased by a large-scale reaction and formal synthesis of (+)-gephyrotoxin.